Downstream synthetic route of 16874-33-2

16874-33-2 Tetrahydrofuran-2-carboxylic acid 86079, aTetrahydrofurans compound, is more and more widely used in various fields.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.16874-33-2,Tetrahydrofuran-2-carboxylic acid,as a common compound, the synthetic route is as follows.

Mixture of 4- (2-fluoro-4-methanesulfonyl-phenoxy)-5-methyl-6- (piperidin-4-yloxy)- pyrimidine (76 mg, 0.2 mmole), tetrahydro-furan-2-carboxylic acid (0.26 mmole, 1.3 eq), HATU (0.26 mmole, 1.3 eq), and TEA (0.4 mmole, 2 eq) in 2 mL THF was heated under microwave irradiation at 120 ¡ã C for 30 minutes. Mixture was purified by HPLC to give compound C164 as a yellow solid (78 mg, 81 percent). H NMR (CDC13, 400 MHz) 8 1.85-2. 17 (M, 8H), 2.21 (s, 3H), 3.10 (s, 3H), 3.75-3. 80 (M, 2H), 3.86-3. 91 (M, 2H), 3.96-4. 01 (M, 2H), 4.68 (t, 1H), 5.40-5. 45 (M, 1H), 7.44 (t, 1H), 7.78-7. 82 (M, 2H), 8.21 (s, 1H). Exact mass calculated for C22H26FN306S 479.2, found 480.3 (MH+)., 16874-33-2

16874-33-2 Tetrahydrofuran-2-carboxylic acid 86079, aTetrahydrofurans compound, is more and more widely used in various fields.

Reference£º
Patent; ARENA PHARMACEUTICALS, INC.; WO2005/7647; (2005); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem