With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5061-21-2,2-Bromo-4-butanolide,as a common compound, the synthetic route is as follows.,5061-21-2
To a solution of 4-bromophenol (5 g, 0.028 mol) in dry N,N-dimethylformamide (50 mL), at 0 C., 60% sodium hydride (1.38 g, 0.05 mol) was added. This was stirred for about 30 minutes at about 0 C. Afterwards, {acute(alpha)}-bromobutyrolactone (7.19 g, 0.043 mol) was added and the reaction mixture was stirred for about 2 hours at 0 C. and subsequently stirred at room temperature for about 1 hour. The reaction mixture was heated to about 100 C. for ?4 hours. Finally, the reaction mixture was quenched with water and extracted in ethyl acetate, the organic layer was washed with brine and water and driedanhydrous sodium sulphate; 15 g of crude product was obtained which was purified in 100-200 mesh size silica gel column chromatography by using 25% ethyl acetate-hexane as eluent to get the desired product Yield: 8 g Mass: 256.69 (M-1)
As the paragraph descriping shows that 5061-21-2 is playing an increasingly important role.
Reference£º
Patent; RANBAXY LABORATORIES LIMITED; Khera, Manoj Kumar; Soni, Ajay; Sattigeri, Jitendra; Sattigeri, Viswajanani; Das, Biswajit; Cliffe, Ian A.; Bhatnagar, Pradip Kumar; Rauf, Abdul Rehman Abdul; Musib, Arpita; Saha, Subham; Yadav, Neeraj Kumar; Ahammed, Sabir; Reddy, Ranadheer R.; Ray, Abhijit; Srivastava, Punit; Dastidar, Sunanda Ghosh; US2014/148459; (2014); A1;,
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