With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.453-20-3,3-Hydroxytetrahydrofuran,as a common compound, the synthetic route is as follows.
To an ice-water cooled solution of tetrahydrofuran-3-ol (5.0 g) in DCM (100 mL)was added TEA (11.9 mL) and MsCI (4.9 mL). The resulting reaction mixture was stirred at 000 for 3 hours, and then quenched with aq. NaHCO3 solution. The mixture was extracted with EA(2×100 mL). The combined organic phases were washed, dried, filtered and concentrated toafford tetrahydrofu ran-3-yl methanesu Ifonate (6.2 g)., 453-20-3
As the paragraph descriping shows that 453-20-3 is playing an increasingly important role.
Reference£º
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; CHEN, Weichun; IGBOKO, Ebere F; LIN, Xichen; LU, Hongfu; REN, Feng; WREN, Paul Bryan; XU, Zhongmiao; YANG, Ting; ZHU, Lingdong; WO2015/181186; (2015); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem