124391-75-9, (S)-(Tetrahydrofuran-3-yl)methanol is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Reference Example 28 2-[(tetrahydrofuran-3-ylmethyl)oxy]pyridine-4-carbonitrile To a suspension (1.0 mL) of sodium hydride (100 mg, 2.50 mmol) in THF was added tetrahydrofuran-3-ylmethanol (138 muL, 1.43 mmol) at room temperature, and the mixture was stirred at 50¡ã C. for 30 min. The reaction mixture was cooled to room temperature, and a solution (1.0 mL) of 2-chloropyridine-4-carbonitrile (200 mg, 1.44 mol) in THF was gradually added at room temperature. The mixture was stirred at room temperature for 30 min. and at 50¡ã C. for 12 hrs. The reaction mixture was cooled to room temperature, water was added and THF was evaporated under reduced pressure. The concentrated residue was extracted with ethyl acetate. The organic layer was washed with saturated brine and, after drying over anhydrous sodium sulfate, concentrated under reduced pressure. The obtained residue was purified by silica gel column chromatography (10percent-20percent ethyl acetate/hexane) to give the title compound as a colorless oil (202 mg, 68percent). 1H-NMR (300 MHz, CDCl3) delta: 1.64-1.83 (1H, m), 2.05-2.20 (1H, m), 2.64-2.86 (1H, m), 3.68 (1H, dd, J=8.9, 5.3 Hz), 3.74-3.84 (1H, m), 3.85-3.96 (2H, m), 4.19-4.42 (2H, m), 6.99 (1H, s), 7.07 (1H, dd, J=5.3, 1.1 Hz), 8.28 (1H, d, J=5.1 Hz)., 124391-75-9
The synthetic route of 124391-75-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Takeda Pharmaceutical Company Limited; Terauchi, Jun; Nara, Hiroshi; Oki, Hideyuki; Sato, Kenjiro; (166 pag.)US2015/329556; (2015); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem