With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.144870-96-2,4-Aminotetrahydrofuran-3-ol,as a common compound, the synthetic route is as follows.
A solution of compound 2 (360 g, 3.5 mmol) in THF (10 mL) was added (Boc)20 (1.14 g,5.25 mmol) and NaOH (2N, 2 mL), then stirred at RT for 1 h. Quenched with water and extractedwith EtOAc, dried and evaporated, purified by combiflash (methanol:DCM = 1:20) to give compound 3 (0.2 g, 28%). LC-MS: m/z = 104.0 [M+H-Boc]
144870-96-2, The synthetic route of 144870-96-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; ABBVIE INC.; MICHAELIDES, Michael; HANSEN, Todd; DAI, Yujia; ZHU, Guidong; FREY, Robin; GONG, Jane; PENNING, Thomas; CURTIN, Michael; MCCLELLAN, William; CLARK, Richard; TORRENT, Maricel; MASTRACCHIO, Anthony; KESICKI, Edward A.; KLUGE, Arthur F.; PATANE, Michael A.; VAN DRIE, John H. Jr.; JI, Zhiqin; LAI, Chunqiu C.; WANG, Ce; (1190 pag.)WO2016/44770; (2016); A1;,
Tetrahydrofuran – Wikipedia
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