With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17347-61-4,2,2-Dimethylsuccinicanhydride,as a common compound, the synthetic route is as follows.
To l’-carboxylic acid tert-butyl ester-6-bromo-spiro[l,3-benzodioxine-2,4′- piperidine] (14.58 g, 37.94 mmol) in ether (300 mL) under argon at -78 0C was added sec- butyllithium (1.4 M; 32.5 mL, 45.5 mmol) dropwise and the reaction was stirred at -78 0C for 30 min. 3,3-Dimethyldihydrofuran-2,5-dione in ether (10 mL) was added and the reaction was stirred for 30 min at -78 0C and quenched with water (-40 mL). The reaction was warmed to rt and concentrated to remove the organic solvents. The aqueous layer was acidified with 5N HCl to pH = 3-4, extracted with dichloromethane (150 mL), and the organic layer was washed with water and brine, dried over sodium sulfate, and concentrated. The product was purified using silica gel column chromatography (2-3% methanol/dichloromethane). The fractions were concentrated, triturated with dichloromethane (~5 mL)/ether (-10 mL)/hexanes (-15-20 mL), and filtered off white solid to obtain 5.52 g (34%); MS m/z: 434 (M + H).
17347-61-4, 17347-61-4 2,2-Dimethylsuccinicanhydride 87067, aTetrahydrofurans compound, is more and more widely used in various fields.
Reference£º
Patent; CEPHALON, INC.; WO2009/97309; (2009); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem