With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.42417-39-0,3-Aminodihydrofuran-2(3H)-one hydrochloride,as a common compound, the synthetic route is as follows.
Under ice bath conditions, 20 g of the amination product white solid was mixed with tetrahydrofuran and water, sodium carbonate was added thereto, and 30 g of benzyl chloroformate was slowly added dropwise to the reaction for half an hour, and then returned to room temperature and then continued. After reacting for 2 hours, the solvent was distilled off under reduced pressure, the pH was adjusted to acidity, and extracted with dichloromethane to give a crude compound of formula IV.Filtration of the product colorless oily liquid 13.54g, yield 90%.
42417-39-0, 42417-39-0 3-Aminodihydrofuran-2(3H)-one hydrochloride 445963, aTetrahydrofurans compound, is more and more widely used in various fields.
Reference£º
Patent; Wuhan Institute of Technology; Jia Lihui; Chen Yunfeng; Chen Changan; (10 pag.)CN109232644; (2019); A;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem