Day: November 4, 2020

453-20-3, 3-Hydroxytetrahydrofuran is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,453-20-3

3-Hydroxytetrahydrofuran (4.4 g, 50 mmol) was dissolved in dichloromethane (50 mL) under ice-cooling,Triethylamine (7.6 g, 75 mmol) was added and stirred for 10 min,Methylsulfonyl chloride (6.3 g, 55 mmol) was slowly added dropwise,After completion of the dropwise addition, the mixture was stirred at room temperature for 1 hour,Washed with saturated aqueous sodium chloride solution (50 mL)The organic phase was concentrated under reduced pressure to give 8.8 g of crude product.

The synthetic route of 453-20-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Shandong Xuanzhu Pharma Co., Ltd.; Wu, Yongqian; (38 pag.)CN104788412; (2017); B;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

184950-35-4, (Tetrahydrofuran-3-yl)methanamine hydrochloride is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Tetrahydrofuran-3-ylmethylamine hydrochloride (0.20 g, 1.44 mmol) And triethylamine (0.15 g, 1.44 mmol) Was added to chloroform (amylene added product) (6 mL). To the mixture, At room temperature 5-cyclopentylmethoxymethyl isoxazole-3-carboxylic acid (0.27 g, 1.20 mmol), 1-Hydroxybenzotriazole (0.02 g, 0.12 mmol) And 1-ethyl-3- (3-dimethylaminopropyl) carbodiimide hydrochloride (0.28 g, 1.44 mmol) After stirring for 5 hours, Dilute hydrochloric acid was added, It was extracted twice with chloroform. The organic layer was washed with saturated sodium bicarbonate water, After drying with anhydrous sodium sulfate, And concentrated under reduced pressure. The residue was subjected to silica gel column chromatography , The following formulaIndicated by N- (tetrahydrofuran-3-ylmethyl) -5-cyclopentylmethoxymethyl isoxazole-3-carboxamide (Hereinafter referred to as amide compound (131)) 0.33 g was obtained., 184950-35-4

The synthetic route of 184950-35-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SUMITOMO CHEMICAL COMPANY LIMITED; SUMITA, YUSUKE; (264 pag.)JP2015/51963; (2015); A;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.42417-39-0,3-Aminodihydrofuran-2(3H)-one hydrochloride,as a common compound, the synthetic route is as follows.

Under ice bath conditions, 20 g of the amination product white solid was mixed with tetrahydrofuran and water, sodium carbonate was added thereto, and 30 g of benzyl chloroformate was slowly added dropwise to the reaction for half an hour, and then returned to room temperature and then continued. After reacting for 2 hours, the solvent was distilled off under reduced pressure, the pH was adjusted to acidity, and extracted with dichloromethane to give a crude compound of formula IV.Filtration of the product colorless oily liquid 13.54g, yield 90%.

42417-39-0, 42417-39-0 3-Aminodihydrofuran-2(3H)-one hydrochloride 445963, aTetrahydrofurans compound, is more and more widely used in various fields.

Reference£º
Patent; Wuhan Institute of Technology; Jia Lihui; Chen Yunfeng; Chen Changan; (10 pag.)CN109232644; (2019); A;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.453-20-3,3-Hydroxytetrahydrofuran,as a common compound, the synthetic route is as follows.

To an ice-water cooled solution of tetrahydrofuran-3-ol (5.0 g) in DCM (100 mL)was added TEA (11.9 mL) and MsCI (4.9 mL). The resulting reaction mixture was stirred at 000 for 3 hours, and then quenched with aq. NaHCO3 solution. The mixture was extracted with EA(2×100 mL). The combined organic phases were washed, dried, filtered and concentrated toafford tetrahydrofu ran-3-yl methanesu Ifonate (6.2 g)., 453-20-3

As the paragraph descriping shows that 453-20-3 is playing an increasingly important role.

Reference£º
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; CHEN, Weichun; IGBOKO, Ebere F; LIN, Xichen; LU, Hongfu; REN, Feng; WREN, Paul Bryan; XU, Zhongmiao; YANG, Ting; ZHU, Lingdong; WO2015/181186; (2015); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5061-21-2,2-Bromo-4-butanolide,as a common compound, the synthetic route is as follows.,5061-21-2

To a solution of 4-bromophenol (5 g, 0.028 mol) in dry N,N-dimethylformamide (50 mL), at 0 C., 60% sodium hydride (1.38 g, 0.05 mol) was added. This was stirred for about 30 minutes at about 0 C. Afterwards, {acute(alpha)}-bromobutyrolactone (7.19 g, 0.043 mol) was added and the reaction mixture was stirred for about 2 hours at 0 C. and subsequently stirred at room temperature for about 1 hour. The reaction mixture was heated to about 100 C. for ?4 hours. Finally, the reaction mixture was quenched with water and extracted in ethyl acetate, the organic layer was washed with brine and water and driedanhydrous sodium sulphate; 15 g of crude product was obtained which was purified in 100-200 mesh size silica gel column chromatography by using 25% ethyl acetate-hexane as eluent to get the desired product Yield: 8 g Mass: 256.69 (M-1)

As the paragraph descriping shows that 5061-21-2 is playing an increasingly important role.

Reference£º
Patent; RANBAXY LABORATORIES LIMITED; Khera, Manoj Kumar; Soni, Ajay; Sattigeri, Jitendra; Sattigeri, Viswajanani; Das, Biswajit; Cliffe, Ian A.; Bhatnagar, Pradip Kumar; Rauf, Abdul Rehman Abdul; Musib, Arpita; Saha, Subham; Yadav, Neeraj Kumar; Ahammed, Sabir; Reddy, Ranadheer R.; Ray, Abhijit; Srivastava, Punit; Dastidar, Sunanda Ghosh; US2014/148459; (2014); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

124391-75-9, (S)-(Tetrahydrofuran-3-yl)methanol is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Reference Example 28 2-[(tetrahydrofuran-3-ylmethyl)oxy]pyridine-4-carbonitrile To a suspension (1.0 mL) of sodium hydride (100 mg, 2.50 mmol) in THF was added tetrahydrofuran-3-ylmethanol (138 muL, 1.43 mmol) at room temperature, and the mixture was stirred at 50¡ã C. for 30 min. The reaction mixture was cooled to room temperature, and a solution (1.0 mL) of 2-chloropyridine-4-carbonitrile (200 mg, 1.44 mol) in THF was gradually added at room temperature. The mixture was stirred at room temperature for 30 min. and at 50¡ã C. for 12 hrs. The reaction mixture was cooled to room temperature, water was added and THF was evaporated under reduced pressure. The concentrated residue was extracted with ethyl acetate. The organic layer was washed with saturated brine and, after drying over anhydrous sodium sulfate, concentrated under reduced pressure. The obtained residue was purified by silica gel column chromatography (10percent-20percent ethyl acetate/hexane) to give the title compound as a colorless oil (202 mg, 68percent). 1H-NMR (300 MHz, CDCl3) delta: 1.64-1.83 (1H, m), 2.05-2.20 (1H, m), 2.64-2.86 (1H, m), 3.68 (1H, dd, J=8.9, 5.3 Hz), 3.74-3.84 (1H, m), 3.85-3.96 (2H, m), 4.19-4.42 (2H, m), 6.99 (1H, s), 7.07 (1H, dd, J=5.3, 1.1 Hz), 8.28 (1H, d, J=5.1 Hz)., 124391-75-9

The synthetic route of 124391-75-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Takeda Pharmaceutical Company Limited; Terauchi, Jun; Nara, Hiroshi; Oki, Hideyuki; Sato, Kenjiro; (166 pag.)US2015/329556; (2015); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.144870-96-2,4-Aminotetrahydrofuran-3-ol,as a common compound, the synthetic route is as follows.

A solution of compound 2 (360 g, 3.5 mmol) in THF (10 mL) was added (Boc)20 (1.14 g,5.25 mmol) and NaOH (2N, 2 mL), then stirred at RT for 1 h. Quenched with water and extractedwith EtOAc, dried and evaporated, purified by combiflash (methanol:DCM = 1:20) to give compound 3 (0.2 g, 28%). LC-MS: m/z = 104.0 [M+H-Boc]

144870-96-2, The synthetic route of 144870-96-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ABBVIE INC.; MICHAELIDES, Michael; HANSEN, Todd; DAI, Yujia; ZHU, Guidong; FREY, Robin; GONG, Jane; PENNING, Thomas; CURTIN, Michael; MCCLELLAN, William; CLARK, Richard; TORRENT, Maricel; MASTRACCHIO, Anthony; KESICKI, Edward A.; KLUGE, Arthur F.; PATANE, Michael A.; VAN DRIE, John H. Jr.; JI, Zhiqin; LAI, Chunqiu C.; WANG, Ce; (1190 pag.)WO2016/44770; (2016); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

124391-75-9, (S)-(Tetrahydrofuran-3-yl)methanol is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 76: Preparation of 5-[5-Fluoro-2-oxo-l,2-dihydro-indoI-(3Z)- yIidenemcthyl]-2,4-dimethyI-lH-pyrroIe-3-carboxylic acid [(R)-3-oxo-2- (tetrahydro-furan-3-yImethyl)-isoxazolidin-4-yl]-amide76a 76b Stepl : To a solution of 76a (250mg 2.45mmol), TEA (273mg, 2.7mmol) inDCM (2OmL) was added methane sulfonyl chloride (298mg, 2.6mmol) drop-wise at O0C. The mixture was stirred overnight at room temperature. After the reaction was complete, the mixture was washed with Na2CO3 solution. The organic phase was separated and the aqueous phase was extracted by DCM (20mL*3). The organic phase was combined, dried over anhydrous Na2SO4 and evaporated to provide 76b (387mg, 88%) as an oil., 124391-75-9

As the paragraph descriping shows that 124391-75-9 is playing an increasingly important role.

Reference£º
Patent; XCOVERY, INC.; WO2008/33562; (2008); A2;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17347-61-4,2,2-Dimethylsuccinicanhydride,as a common compound, the synthetic route is as follows.

To l’-carboxylic acid tert-butyl ester-6-bromo-spiro[l,3-benzodioxine-2,4′- piperidine] (14.58 g, 37.94 mmol) in ether (300 mL) under argon at -78 0C was added sec- butyllithium (1.4 M; 32.5 mL, 45.5 mmol) dropwise and the reaction was stirred at -78 0C for 30 min. 3,3-Dimethyldihydrofuran-2,5-dione in ether (10 mL) was added and the reaction was stirred for 30 min at -78 0C and quenched with water (-40 mL). The reaction was warmed to rt and concentrated to remove the organic solvents. The aqueous layer was acidified with 5N HCl to pH = 3-4, extracted with dichloromethane (150 mL), and the organic layer was washed with water and brine, dried over sodium sulfate, and concentrated. The product was purified using silica gel column chromatography (2-3% methanol/dichloromethane). The fractions were concentrated, triturated with dichloromethane (~5 mL)/ether (-10 mL)/hexanes (-15-20 mL), and filtered off white solid to obtain 5.52 g (34%); MS m/z: 434 (M + H).

17347-61-4, 17347-61-4 2,2-Dimethylsuccinicanhydride 87067, aTetrahydrofurans compound, is more and more widely used in various fields.

Reference£º
Patent; CEPHALON, INC.; WO2009/97309; (2009); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

19311-37-6, 3-Bromotetrahydrofuran is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 36 Synthetic Scheme 36: (+/-)-4-(3-(2-chloro-4-(tetrahydrofuran-3-yl)phenyl)-1,4-oxazepan-4-yl)-6-methylpyrimidin-2-amine (279) I-238 A pyrex tube was charged with 3-bromotetrahydrofuran (0.027 g, 0.179 mmol) dichloronickel; 1,2-dimethoxyethane (0.003 g, 0.014 mmol), 1,10-phenanthroline (0.005 g, 0.028 mmol), BF4 (Sodium salt) (0.007 g, 0.064 mmol), manganese (0.013 g, 0.237 mmol). The reaction mixture was bubbled with nitrogen for 5 minutes. To the mixture was added MeOH (4 mL), 4-ethylpyridine (0.007 g, 0.061 mmol) and followed with 4-[3-(4-bromo-2-chloro-phenyl)-1,4-oxazepan-4-yl]-6-methyl-pyrimidin-2-amine, 31, (0.050 g, 0.121 mmol). The mixture was stirred at 55 C. overnight. The reaction mixture was diluted with EtOAc, filtered though a layer of celite and concentrated in vacuo. The resulting residue was purified by silica gel chromatography using a 4 g ISCO silica gel cartridge eluting with 0-10% MeOH. The product recovered was repurified by reverse phase chromatography. To afford 6.7 mg of desired product: 1H NMR (400 MHz, CDCl3) delta 7.30 (d, J=1.7 Hz, 1H), 7.24 (d, J=3.2 Hz, 1H), 7.18 (d, J=8.0 Hz, 1H), 7.11 (d, J=8.1 Hz, 1H), 5.58 (s, 1H), 4.90 (s, 2H), 4.51-4.26 (m, 1H), 4.18-4.05 (m, 2H), 3.92 (q, J=7.8 Hz, 1H), 3.73 (ddd, J=8.7, 7.0, 1.8 Hz, 1H), 3.69-3.49 (m, 3H), 3.37 (p, J=7.6 Hz, 1H), 2.45-2.27 (m, 1H), 2.17 (s, 3H), 2.08-1.95 (m, 2H); ESI-MS m/z calc. 388.2, found 389.0 (M+1)+. Retention time: 3.06 minutes.

19311-37-6, 19311-37-6 3-Bromotetrahydrofuran 12929516, aTetrahydrofurans compound, is more and more widely used in various fields.

Reference£º
Patent; Merck Patent GmbH; Vertex Pharmaceuticals Incorporated; Yu, Henry; Clark, Michael; Bemis, Guy; Boyd, Michael; Chandupatla, Kishan; Collier, Philip; Deng, Hongbo; Dong, Huijun; Dorsch, Warren; Hoover, Russell R.; Johnson, JR., Mac Arthur; Kukarni, Shashank; Penney, Marina; Ronkin, Steven; Takemoto, Darin; Tang, Qing; Waal, Nathan D.; Wang, Tiansheng; (254 pag.)US2019/322658; (2019); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem