97-99-4,97-99-4, (Tetrahydrofuran-2-yl)methanol is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To the product of Example 1E (0.10 g, 0.23 mmol) in THF (5 mL) was added potassium tert-butoxide (0.053 g, 0.47 mmol). The mixture was stirred at ambient temperature for 20 min then (R)-(tetrahydrofuran-2-yl)methanol (Fluka, 0.023 mL, 0.23 mmol) in THF (5 mL) was added via cannula. The mixture was stirred for 1 h at ambient temperature then was quenched with saturated, aqueous NH4Cl (3 mL) and diluted with EtOAc (3 mL). The layers were separated and the aqueous layer was extracted with EtOAc (3¡Á5 mL). The combined organics were dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure. The crude material was purified by column chromatography (SiO2, 50% hexanes in EtOAc to 100% EtOAc to 10% MeOH in EtOAc) to give the title compound (40 mg, 0.078 mmol, 34% yield). 1H NMR (300 MHz, CDCl3) delta ppm 1.43 (s, 9H), 1.68-1.81 (m, 2H), 1.82-1.96 (m, 4H), 1.97-2.11 (m, 2H), 3.66-3.80 (m, 3H), 3.85 (s, 3H), 3.86-3.93 (m, 1H), 3.99-4.06 (m, 1H), 4.10-4.22 (m, 2H), 4.25-4.36 (m, 2H), 4.46-4.54 (m, 1H), 6.99-7.04 (m, 1H), 7.00 (s, 1H), 7.44-7.51 (m, 1H), 7.96 (d, J=2.4 Hz, 1H); MS (DCI/NH3) m/z 510 (M+H)+
As the paragraph descriping shows that 97-99-4 is playing an increasingly important role.
Reference£º
Patent; ABBOTT LABORATORIES; US2010/69348; (2010); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem