With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.22929-52-8,Dihydrofuran-3(2H)-one,as a common compound, the synthetic route is as follows.
22929-52-8, EXAMPLE 1 7-Oxa-1,3-diazaspiro[4.4]nonane-2,4-dione STR8 A solution of 19.2 g of ammonium carbonate in 42 ml of ethanol and 28 ml of water is added to 10.0 g of 3-ketotetrahydrofuran. The resulting mixture is heated to 55¡ã and to it is then added, dropwise, a solution of 6.3 g of potassium cyanide in 15 ml of water. The reaction mixture is stirred at 55¡ã for 18 hrs. Thereafter the reaction mixture is evaporated in vacuo to dryness to obtain a residue. The residue is dissolved in a minimum of water and the mixture made acidic with 2 N hydrochloric acid. The first crop of the title product precipitates out on cooling and is filtered off. A second crop of the title product is obtained by concentrating the filtrate and cooling. The two combined crops are recrystallized from ethanol to give refined title product, m.p. 202¡ã-204¡ã.
22929-52-8 Dihydrofuran-3(2H)-one 529392, aTetrahydrofurans compound, is more and more widely used in various fields.
Reference£º
Patent; Sandoz, Inc.; US4320135; (1982); A;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem