With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.87219-29-2,(S)-Benzyl (5-oxotetrahydrofuran-3-yl)carbamate,as a common compound, the synthetic route is as follows.
87219-29-2, Preparation of (S)-tert-butyl 3-(cyclopropyl(2,3-dichlorobenzyl)carbamoyl)-4-(4-hydroxyphenyl)-2-((methoxymethoxy)methyl)-5,6-dihydropyridine-1(2H)-carboxylate (4H) 4A (S)-Benzyl-4-(cyclopropyl(2,3-dichlorobenzyl)amino)-1-hydroxy-4-oxobutan-2-ylcarbamate (4A) Into a 100 mL round bottom flask fitted with a reflux condenser and a nitrogen inlet, N-(2,3-dichlorobenzyl)cyclopropanamine (30.3 g, 140.3 mmol) (Example 1A) and (S)-benzyl 5-oxotetrahydrofuran-3-ylcarbamate (22.0 g, 93.5 mmol) were added. The mixture was heated without solvent at 100 C. for 24 hours. Purification by column chromatography (5%->10% MeOH/dichloromethane) gave 22.0 g (52%) of 4A. ESI-MS:m/z 451.3 (M+H)+.
As the paragraph descriping shows that 87219-29-2 is playing an increasingly important role.
Reference£º
Patent; Takeda Pharmaceutical Company Limited; US8129538; (2012); B1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem