With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.184950-35-4,(Tetrahydrofuran-3-yl)methanamine hydrochloride,as a common compound, the synthetic route is as follows.
5-bromo-pyridine-2-carboxylic acid (15.00g, 74.3mmol) of ethyl acetate (200 mL) suspension of thionyl chloride (6.2mL, 85.4mmol) and N, N-dimethylformamide (about 0. 2mL) was added, and the mixture was stirred for 2 hours and 30 minutes at 75 . After concentration under reduced pressure, diluted with toluene (150 mL). 5 cooled to below (tetrahydrofuran-3-yl) methylamine hydrochloride (11.24g, 81.7mmol) and 2 mol / L aqueous sodium hydroxide solution (100 mL)Was added simultaneously, after 2 hours of stirring at 5 or less, water was added and extracted twice with ethyl acetate. The organic layer was washed with saturated brine, dried over magnesium sulfate and concentrated under reduced pressure. The residue was suspended in diisopropyl ether, the precipitates by filtration, to obtain a represented by the following formula N- (tetrahydrofuran-3-ylmethyl) -5-bromopyridine-2-carboxylic acid amide 16.95 g., 184950-35-4
As the paragraph descriping shows that 184950-35-4 is playing an increasingly important role.
Reference£º
Patent; SUMITOMO CHEMICAL COMPANY LIMITED; AWASAGUCHI, KENICHIRO; (106 pag.)JP2016/11276; (2016); A;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem