104227-71-6, (S)-tert-Butyl (5-oxotetrahydrofuran-3-yl)carbamate is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Step 1: At -10 C,Diisopropylamine (436 mg, 4.3 mmol) and n-butyllithium (2.5 M, 1.7 mL,A solution of 4.3 mmol) in tetrahydrofuran (1 mL) was stirred for 10 minutes and then the reaction was cooled to -70 C. A solution of (S)-(5-oxotetrahydrofuran-3-yl)carbamic acid tert-butyl ester (289 mg, 1.4 mmol) in tetrahydrofuran (1 mL) was slowly added dropwise to the above reaction system, and the obtained mixture was stirred for 30 minutes. A white solid is formed. Then, a solution of the compound Ia-5 (280 mg, 0.72 mmol) in tetrahydrofuran (1 mL) was slowly added dropwise to the above reaction system. The resulting mixture was stirred at -40 C for 30 minutes. The reaction system was quenched with saturated aqueous sodium hydrogen sulfate and extracted with EtOAc. Separating organic phase, there isThe machine phase is dried over anhydrous sodium sulfate, filtered and concentrated.Rapid column chromatography (petroleum ether/ethyl acetate = 4/1)Purification afforded compound 4-6 (370 mg, yield: 87%) as a colourless oil.
104227-71-6, The synthetic route of 104227-71-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Shanghai Dinuo Pharmaceutical Technology Co., Ltd.; Gao Daxin; Chen Shoujun; Liu Fengtao; (47 pag.)CN108148022; (2018); A;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem