16874-33-2, Tetrahydrofuran-2-carboxylic acid is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of tetrahydro-furan-2-carboxylic acid (2. 42 g, 20. 82 mmol) in anhydrous tetrahydrofuran (120 mL), under an atmosphere of nitrogen at 0 C, was added triethylamine (8. 5 mL, 61. 23 MMOL) and ethyl chloroformate (2. 4 ML, 25. 10 MMOL). White precipitation formed after the addition of ethyl chloroformate and the resulting mixture stirred for 45 minutes at 0 C. Ammonia gas was bubbled into the solution for 2 hours and the gas source removed. The reaction mixture was then allowed to warm to ambient temperature and stirred for 16 hours. The solution was adjusted to pH 1 by addition of 1 N hydrochloric acid, and then extracted with ethyl acetate (3 x 50 mL). The combined organic extracts were dried (anhydrous magnesium sulfate), filtered, and concentrated in vacuo to give the crude product. The residue was purified by flash column chromatography (hexanes to 10% ethyl acetate/hexanes) to afford the title compound (0. 97 g, 41%) as a white solid. LRMS (MILZ) : 116 (M+H) +. ‘H NMR (CDCI3, 300 MHz) : 4. 35 (1H, dd, J= 8. 5, 5. 8 HZ), 3. 92 (2H, m), 2. 18 (2H, m), 1. 90 (2H, m)., 16874-33-2
As the paragraph descriping shows that 16874-33-2 is playing an increasingly important role.
Reference£º
Patent; PFIZER INC.; WO2004/92145; (2004); A1;,
Tetrahydrofuran – Wikipedia
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