With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1679-47-6,3-Methyldihydrofuran-2(3H)-one,as a common compound, the synthetic route is as follows.
To a solution of diisopropylamine (2.3 mL, 16.16 mmol) in tetrahydrofuran (THF) (37 mL),N-Butyllithium (2.5 M in hexanes, 5.92 mL, 14.81 mmol) was added with stirring at -78 C. After stirring for 5 minutes,Alpha-methyl-gamma-butyrolactone(1.416 mL, 14.81 mmol) was added dropwise.After stirring at 0 C for 15 minutes,The reaction mixture is cooled to -75 C.2,6-Dichloropyrazine (2.0059 g, 13.46 mmol) was added dropwise as a solution in THF (7.5 mL). The mixture was stirred overnight while warming to room temperature.Dilute the reaction mixture with saturated aqueous sodium bicarbonate solution,Extracted with dichloromethane (2 ¡Á 10 mL).The combined extracts are dehydrated with anhydrous sodium sulfate,Filter and concentrate under reduced pressure. ProductPurify by silica gel chromatography eluting with 0-40% ethyl acetate / heptane,The desired product (2.5 g, 76% yield) was obtained.
1679-47-6, The synthetic route of 1679-47-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Abbvie Incorporated; Argiriadi, Maria A.; Breinlinger, Eric C.; Chien, Ellen Yulin Tsai; Cowart, Marlon D.; Frank, Kristine E.; Friedman, Michael M.; Hardy, David J.; Herold, J. Martin; Liu, Huaqing; Chu, Wei; Scanio, Marc J.; Schrimpf, Michael R.; Vargo, Thomas R.; Van Epps, Stacy A.; Webster, Matthew P.; Little, Andrew J.; Dunstan, Teresa A.; Katcher, Matthew H.; Schedler, David A.; (232 pag.)JP6557436; (2019); B1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem