Day: October 23, 2020

4100-80-5, 3-Methyldihydrofuran-2,5-dione is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

0.190 mmol of 3-methyldihydrofuran-2,5-dione is added to a solution of 0.173 mmol of 2′-benzyl-2′-azabicyclo[2.2.1]hept-7′-ylmethyl 2-amino-5-bromobenzoate, obtained in accordance with Example 3, in 1 ml of acetic acid, and the mixture is heated at 80¡ã C. for 12 hours. The mixture is subjected to conventional work-up, giving 2-benzyl-2-azabicyclo[2.2.1]hept-7-ylmethyl 5-bromo-2-(3′-methyl-2′,5′-dioxopyrrolidin-1′-yl)benzoate; ESI 512; salt precipitation using 0.5M HCl solution gives 2-benzyl-2-azabicyclo[2.2.1]hept-7-ylmethyl 5-bromo-2-(3′-methyl-2′,5′-dioxopyrrolidin-1′-yl)benzoate hydrochloride., 4100-80-5

The synthetic route of 4100-80-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Schiemann, Kai; Leibrock, Joachim; US2004/110788; (2004); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13031-04-4,4,4-Dimethyldihydrofuran-2,3-dione,as a common compound, the synthetic route is as follows.,13031-04-4

A rhodium catalyst precursor [Rh(COD)Cl]2, a chiral bisphosphine ligand 3 (R1 = Boc), a polyether alkylguanidinium salt ionic liquid [ (PG), CH3 (EO) 16TMG] SO3CH3, ketopantolactone and benzene, the molar ratio of 3 to Rh is 1.1: 1, the mass ratio of ionic liquid to rhodium catalyst precursor is 500: 1, the ratio of ketopantolactone to Rh The molar ratio is 100: 1, the volume ratio of benzene to ionic liquid is 4: 1, the atmosphere is replaced with nitrogen or argon for 4-6 times, and then pressurized with hydrogen to 5.0MPa, the reaction is carried out at 50 for 4 hours and then rapidly cooled After hydrogen was vented, the benzene was removed under reduced pressure and extracted twice with methyl tert-butyl ether. The volume ratio of methyl tert-butyl ether to benzene was 1: 1. The system was split into two phases and was isolated by simple phase separation The upper methyl tert-butyl ether phase containing D-pantolactone was analyzed by gas chromatography. The conversion of ketopantolactone was 77.6%, and the ee value of D-pantolactone was 60.7%. The reaction conditions and procedures were the same as in Example 1 except that the solvent was changed to toluene, the molar ratio of ketopantolactone to Rh was 200: 1, the pressure of hydrogen was 0.1 MPa, the reaction temperature was 25 C, and the reaction time was 2h. Analysis by gas chromatography showed that the conversion rate of ketopantolactone was 97.5% and that of D-pantolactone was 92.2%.

The synthetic route of 13031-04-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Qingdao University of Science and Technology; Jin Xin; Li Shumei; Cui Feifei; (8 pag.)CN104761518; (2017); B;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

52079-23-9, (S)-(-)-alpha-Hydroxy-gamma-butyrolactone is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Methanesulfonic acid 2-oxo-tetrahydro-furan-3S-yl ester Methanesulfonyl chloride (1.67 ml, 21.56 mmol) was added to a stirred solution of (S)-3-hydroxy-2-oxo-tetrahydrofuran (2 g, 19.6 mmol), 4-N,N-dimethylaminopyridine (240 mg, 1.96 mmol) and diisopropylethylamine (3.76 ml, 21.56 mmol) in dry dichloromethane (20 ml), under nitrogen, at -40 C. The mixture was stirred for 30 minutes and then allowed to warm up to room temperature, then it was washed with 2M hydrochloric acid solution (50 ml), dried and evaporated to a solid. The crude product was purified by flash chromatography on silica gel, eluding with ethyl acetate-cyclohexane (1:1). Trituration with diethylether and drying in vacuo afforded the title compound as a crystalline white solid (2.23 g, 63%): mp. 70-75 C.; NMR delta (CDCl3) 5.33 (1H, t, J 8 Hz), 4.53 (1H, dt, J 9 and 2 Hz), 4.34 (1H, dt, J 10 and 6 Hz), 3.28 (3H, s), 2.86-2.72 (1H, m), 2.65-2.47 (1H, m)., 52079-23-9

The synthetic route of 52079-23-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Glaxo Wellcome Inc.; US6197761; (2001); B1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.184950-35-4,(Tetrahydrofuran-3-yl)methanamine hydrochloride,as a common compound, the synthetic route is as follows.

Tetrahydrofuran-3-ylmethylamine hydrochloride (0.20 g, 1.20 mmol) And triethylamine (0.12 g, 1.20 mmol) Was added to chloroform (amylene added product) (4 mL). To the mixture, Butyl-2H-1,2,3-triazole-4-carboxylic acid (0.17 g, 1.00 mmol) at room temperature, 1-Hydroxybenzotriazole (0.01 g, 0.10 mmol) And 1-ethyl-3- (3-dimethylaminopropyl) carbodiimide hydrochloride (0.23 g, 1.20 mmol) After stirring for 3 hours, Dilute hydrochloric acid was added, It was extracted twice with chloroform. The organic layer was washed with saturated sodium bicarbonate water, The filtrate was concentrated under reduced pressure. The residue was subjected to silica gel column chromatography, Represented by the following equation N- (Tetrahydrofuran-3-ylmethyl) -2-butyl-2H-1,2,3-triazole-4-carboxamide (Hereinafter referred to as the present amide compound (55))0.11 g.

184950-35-4, The synthetic route of 184950-35-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SUMITOMO CHEMICAL COMPANY LIMITED; SUMITA, YUSUKE; (264 pag.)JP2015/51963; (2015); A;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

111769-27-8, (R)-Tetrahydrofuran-3-amine 4-methylbenzenesulfonate is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Pyridin-4-ylmethyl (3R)-tetrahydrofuran-3-ylcarbamate To a solution of 4-nitrophenyl (pyridin-4-yl)methyl carbonate (Intermediate 1; 274 mg, 1.0 mmol) and DMAP (122 mg, 1.0 mmol) in DMF (5 mL) was added a solution of (R)- tetrahydrofuran-3 -amine toluenesulfonate (259 mg, 1.0 mmol) and DIPEA (174 muL, 1.0 mmol) in DMF (5 mL). The reaction mixture was stirred for 24 hours and then concentrated in vacuo. The residue was purified by normal phase chromatography(gradient eluting with MeOH in DCM from 0% to 2%) and dried in vacuo to give pyridin- 4-ylmethyl (3R)-tetrahydrofuran-3-ylcarbamate (68 mg, 31%) as an off white solid.Analytical HPLC: purity >99% (System A, Rtau = 2.72 min); Analytical LCMS: purity 100% (System C, Rtau = 3.32 min), ES+: 222.8 [MH]+; HRMS calcd for CnHi4N2O3: 222.1004, found 222.1007.

111769-27-8, As the paragraph descriping shows that 111769-27-8 is playing an increasingly important role.

Reference£º
Patent; BIOVITRUM AB (PUBL); WO2009/147216; (2009); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.42417-39-0,3-Aminodihydrofuran-2(3H)-one hydrochloride,as a common compound, the synthetic route is as follows.

The autocatalytic reaction of homoserine lactone hydrochloride was performed using a high pressure reaction system. Specifically, 2 g of HSL.HCl, 45 g of chloroform and 1 g of conc. HCl was added to the reactor and reacted with NO / Air (O2) gas at room temperature (25 ) and high pressure (about 14 atm). After 2 hours of reaction, the product was recovered and the components were analyzed as 92.7% of Cl-GBL, 3.3% of HO-GBL, 3.8% of furanone and 0.2% of other components.

42417-39-0, As the paragraph descriping shows that 42417-39-0 is playing an increasingly important role.

Reference£º
Patent; CJ CHEILJEDANG CORPORATION; KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY; YANG, YOUNG RYEOL; KIM, BYUNG SIK; KIM, JEONG HYUN; LEE, JUNG HO; SHIN, HYUN KWAN; KIM, JU NAM; CHO, KYUNG HO; (40 pag.)KR2015/118287; (2015); A;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

16874-33-2, Tetrahydrofuran-2-carboxylic acid is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of tetrahydro-furan-2-carboxylic acid (2. 42 g, 20. 82 mmol) in anhydrous tetrahydrofuran (120 mL), under an atmosphere of nitrogen at 0 C, was added triethylamine (8. 5 mL, 61. 23 MMOL) and ethyl chloroformate (2. 4 ML, 25. 10 MMOL). White precipitation formed after the addition of ethyl chloroformate and the resulting mixture stirred for 45 minutes at 0 C. Ammonia gas was bubbled into the solution for 2 hours and the gas source removed. The reaction mixture was then allowed to warm to ambient temperature and stirred for 16 hours. The solution was adjusted to pH 1 by addition of 1 N hydrochloric acid, and then extracted with ethyl acetate (3 x 50 mL). The combined organic extracts were dried (anhydrous magnesium sulfate), filtered, and concentrated in vacuo to give the crude product. The residue was purified by flash column chromatography (hexanes to 10% ethyl acetate/hexanes) to afford the title compound (0. 97 g, 41%) as a white solid. LRMS (MILZ) : 116 (M+H) +. ‘H NMR (CDCI3, 300 MHz) : 4. 35 (1H, dd, J= 8. 5, 5. 8 HZ), 3. 92 (2H, m), 2. 18 (2H, m), 1. 90 (2H, m)., 16874-33-2

As the paragraph descriping shows that 16874-33-2 is playing an increasingly important role.

Reference£º
Patent; PFIZER INC.; WO2004/92145; (2004); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1679-47-6,3-Methyldihydrofuran-2(3H)-one,as a common compound, the synthetic route is as follows.

To a solution of diisopropylamine (2.3 mL, 16.16 mmol) in tetrahydrofuran (THF) (37 mL),N-Butyllithium (2.5 M in hexanes, 5.92 mL, 14.81 mmol) was added with stirring at -78 C. After stirring for 5 minutes,Alpha-methyl-gamma-butyrolactone(1.416 mL, 14.81 mmol) was added dropwise.After stirring at 0 C for 15 minutes,The reaction mixture is cooled to -75 C.2,6-Dichloropyrazine (2.0059 g, 13.46 mmol) was added dropwise as a solution in THF (7.5 mL). The mixture was stirred overnight while warming to room temperature.Dilute the reaction mixture with saturated aqueous sodium bicarbonate solution,Extracted with dichloromethane (2 ¡Á 10 mL).The combined extracts are dehydrated with anhydrous sodium sulfate,Filter and concentrate under reduced pressure. ProductPurify by silica gel chromatography eluting with 0-40% ethyl acetate / heptane,The desired product (2.5 g, 76% yield) was obtained.

1679-47-6, The synthetic route of 1679-47-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Abbvie Incorporated; Argiriadi, Maria A.; Breinlinger, Eric C.; Chien, Ellen Yulin Tsai; Cowart, Marlon D.; Frank, Kristine E.; Friedman, Michael M.; Hardy, David J.; Herold, J. Martin; Liu, Huaqing; Chu, Wei; Scanio, Marc J.; Schrimpf, Michael R.; Vargo, Thomas R.; Van Epps, Stacy A.; Webster, Matthew P.; Little, Andrew J.; Dunstan, Teresa A.; Katcher, Matthew H.; Schedler, David A.; (232 pag.)JP6557436; (2019); B1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.184950-35-4,(Tetrahydrofuran-3-yl)methanamine hydrochloride,as a common compound, the synthetic route is as follows.,184950-35-4

Tetrahydrofuran-3-ylmethylamine hydrochloride (0.22 g, 1.60 mmol) And triethylamine (0.16 g, 1.60 mmol) Was added to chloroform (amylene added product) (8 mL). To the mixture, 5- (5-phenylfurfuryl) oxymethylisoxazole-3-carboxylic acid (0.40 g, 1.34 mmol) at room temperature, 1-Hydroxybenzotriazole (0.02 g, 0.13 mmol) And 1-ethyl-3- (3-dimethylaminopropyl) carbodiimide hydrochloride (0.31 g, 1.60 mmol) were added, After stirring for 3 hours, Dilute hydrochloric acid was added, It was extracted twice with chloroform. The organic layer was washed with saturated sodium bicarbonate water, And concentrated under reduced pressure. The residue was subjected to silica gel column chromatography, The following equationIndicated by N- (tetrahydrofuran-3-ylmethyl) -5- (5-phenylfurfuryl) oxymethyl isoxazole-3-carboxamide (Hereinafter referred to as the present amide compound (12 4)) 0.35 g was obtained.

As the paragraph descriping shows that 184950-35-4 is playing an increasingly important role.

Reference£º
Patent; SUMITOMO CHEMICAL COMPANY LIMITED; SUMITA, YUSUKE; (264 pag.)JP2015/51963; (2015); A;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

57595-23-0, Methyl 4-oxotetrahydrofuran-3-carboxylate is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

57595-23-0, (b) Tetrahydrofuran-3-one A solution of methyl 3-oxo-tetrahydrofuranyl-4-carboxylate (14.5 g, 0.1 mol) in 10percent H2 SO4 (50 ml) was refluxed for 1 hour. The reaction mixture was cooled and extracted with ether (3*100 ml). The organic layers were combined, dried over MgSO4 and concentrated in vacuo. The pale gold residue was distilled to afford 6.8 g (79percent) of tetrahydrofuran-3-one, B.P. 74¡ã-75¡ã C. at 100 mm Hg.

57595-23-0 Methyl 4-oxotetrahydrofuran-3-carboxylate 14666564, aTetrahydrofurans compound, is more and more widely used in various fields.

Reference£º
Patent; Sterling Winthrop Inc.; US5294612; (1994); A;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem