17347-61-4, 2,2-Dimethylsuccinicanhydride is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Step 6: Synthesis of 4-(lR,3aS,5aR,5bR,7aR,9S, l laR,l lbR,13aR,13bR)-3a-((R)-2-(5-(4- chloro phenyl)- 1 H-imidazo l-2-yl)pyrro lidine- 1 -carbonyl)-5 a,5b, 8 ,8,11 a-pentamethyl- 1 – (prop- 1 -en-2-yl) icosahydro- 1 H-cyclopenta[a]chrysen-9-yl)oxy)-2,2-dimethyl-4-oxobutanoic acid: [0225] To a stirred solution of (R)-2-(5-(4-chlorophenyl)-lH-imidazol-2- yl)pyrrolidin-l -yl)(( lR,3aS,5aR,5bR,7aR,9S, 11 aR, 1 IbR, 13aR, 13bR)-9-hydroxy- 5a,5b,8,8,l la-pentamethyl-l-(prop-l-en-2-yl)icosahydro-3aH-cyclopenta[a]chrysen-3a- yl)methanone (step 5, 0.300 g, 0.43 mmol, 1.0 eq) and 2,2-dimethyl succinicanhydride (0.22 g, 1.75 mmol, 4.0 eq) in toluene (7.5 mL) was added DMAP (0.10 g, 0.87 mmol, 2.0 eq). The reaction mixture was heated at 90¡ãC for overnight. TLC indicated starting material was consumed and the desired product was observed. The mixture was concentrated under reduced pressure, cooled to 0¡ãC, acidified to pH= 5 with IN HC1 and extracted with CH2CI2. The combined organic extracts were washed with water, dried over Na2S04, filtered and evaporated under reduced pressure. The crude residue was purified by column chromatography by using 2percent methanol: dichloromethane as an eluent to gave the desired product (0.150 g, 43.0percent) as a white solid. H1 NMR (DMSO-d6, 300 MHz): delta 12.16 (s, 1H), 11.67 (s, 1H), 7.74 (d, 2H), 7.48 (s. 1H), 7.36 (d, 2H), 5.04 (s, 1H), 4.54 (d, 2H), 4.36 (t, 1H), 3.78 (s, 1H), 3.56 (bs, 2H), 2.08 (m 1H), 2.38-1.85 (m, 9H), 1.58-1.32 (m, 15H), 1.16 (m, 7H), 0.93-0.87 (m, 10H) and 0.83-0.78 (m, 12H); Mass: [M]+ 814.53 (100percent); HPLC: 89.00percent., 17347-61-4
The synthetic route of 17347-61-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; HETERO RESEARCH FOUNDATION; PANDURANGA REDDY, Adulla; PARTHASARADHI REDDY, Bandi; RATHNAKAR REDDY, Kura; VL SUBRAHMANYAM, Lanka; DAVID KRUPADANAM, Gazula, Levi; VENKATI, Mukkera; SUDHAKAR, Neela; SRINIVAS REDDY, Kallem; WO2014/105926; (2014); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem