112372-15-3, Furo[2,3-c]pyridine-2-carboxylic acid is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a suspension of furo[2,3-c] pidine-2-carboxylic acid (0.030 g, 0.47 1 mmol), 5-((2- (pidin-3 -yl) phenoxy) methyl)-4, 5 -dihydroisoxazol-3 -yl) methanamine dihydrochloride (¡À) (0.050 g, 0.156 mmol) in N,N-dimethylformamide (2 mL) wasadded BOP reagent (0.076 g, 0.172 mmol) and N,N-diisopropylethylamine (0.200 mL,1.286 mmol) at -5C under nitrogen atmosphere. Reaction mixture was stirred at room temperature for 14 h. The reaction mixture was poured onto ice water, extracted with ethyl acetate (2 x 15 mL). The combined ethyl acetate layer was washed with water, brine solution (2 x 5 mL). The organic phase was dried over sodium sulfate and concentrated under reduced pressure to give a residue. The residue was purified bycolumn chromatography (methanolldichloromethane = 4/96) to give the titled compound(0.012 g, 21%) as a solid. HPLC: 94.23 %; LCMS: m/z 430.2 [M+2] 1H NMR (400MHz, Chloroform-d) 8.88 (s, 1H), 7.72 – 7.52 (m, 5H), 7.48 (s, 1H), 7.21 – 7.07 (m,3H), 6.76 (td, J= 7.5, 1.1 Hz, 1H), 6.67 (d, J= 8.1 Hz, 1H), 4.99 (ddt, J= 10.7, 7.3, 4.0Hz, 1H), 4.45 (dd, J = 17.2, 5.8 Hz, 1H), 4.32 (dd, J = 17.2, 5.3 Hz, 1H), 3.36 (dt, J =13.2, 3.8 Hz, 1H), 3.29- 3.15 (m, 2H), 2.94 (dd, J= 17.3, 6.7 Hz, 1H)., 112372-15-3
112372-15-3 Furo[2,3-c]pyridine-2-carboxylic acid 13803072, aTetrahydrofurans compound, is more and more widely used in various fields.
Reference£º
Patent; AURIGENE DISCOVERY TECHNOLOGIES LIMITED; CHIKKANNA, Dinesh; KHAIRNAR, Vinayak; PANIGRAHI, Sunil Kumar; WO2014/111871; (2014); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem