112372-15-3, Furo[2,3-c]pyridine-2-carboxylic acid is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A solution of [5-[4-(pyrrolidin-1-yl)piperidine-l -sulfonyl]pyridin-2-yl]methanamine (72 mg, 022 mmol, 1.00 equiv), furo[2,3-c]pyridine-2-carboxylic acid (40 mg, 0,25 mmol, 1.10 equiv), EDCI (85 mg, 0.44 mmol, 2.00 equiv), HOBt (36 mg, 0.27 mmol, 1.20 equiv), and tnethylamine (67.3 mg, 0.67 mmol, 3.00 equiv) in DMF (10 mL) was stirred for 1.5 h at rt. The reaction was then quenched by the addition of 50 mL of water and the resulting solution was extracted with 3×50 mL of ethyl acetate. The combined organic layers were washed with 3×100 mL of brine, dried over anhydrous sodium sulfate, and then concentrated under vacuum. The residue was purified on a silica gel column eluted with dichloromethane/methanol (50: 1 to 20: 1 ) to give 143 mg ( 14%) of the title compound as a light yellow solid LC MS (Method H, F.SI): RT = 101 min, m z = 470.0 [M+H] ‘ . 1HNMR (400 MHz, DMSO-d6) 5969-9.65 (t, J = 6 Hz, 1H), 9.08 (s, 1H), 8.85-8.84 (d,J= 2.1 Hz, 1H), 8.50-8.48 (d,J = 5.1 Hz, 1H), 8.15-8.11 (dd, J= 2.4, 8.4 Hz, 1H), 7.85-7.83 (d, J=5.1 Hz, 1H), 7.69-7.62 (d, J = 8.1 Hz, 2H), 4.72- 4.70 (d, J = 60 Hz, 2H), 3.50-3.47 (d, J=96 Hz, 2H), 2.50-249 (m, 6H), 2.05-2.01 (m, 1H), 1.87-1.84 (d, J = 108Hz,2H), 1.62 (s,4H), 1.45-1.38 (m, 2H)., 112372-15-3
As the paragraph descriping shows that 112372-15-3 is playing an increasingly important role.
Reference£º
Patent; GENENTECH, INC.; FORMA TM, LLC; BAIR, Kenneth W.; BAUMEISTER, Timm R.; DRAGOVICH, Peter; GOSSELIN, Francis; YUEN, Po-Wai; ZAK, Mark; ZHENG, Xiaozhang; WO2013/127267; (2013); A1;,
Tetrahydrofuran – Wikipedia
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