With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5061-21-2,2-Bromo-4-butanolide,as a common compound, the synthetic route is as follows.
5061-21-2, To a solution of 8.5 ml toluene, 3.03 g (25 mmol) of 2,6-dimethylphenylamine and 4.12 (25 mmol) of 3-bromo-dihydrofuran-2(3H)-one, heated to 80 C, a solution of 1.73 g (12.5 mmol) of K2CO3 in 5 ml of water was added dropwise over 5 h. After cooling, the mixture was washed with 5% solution of KHCO3 (10 ml) and water (3 * 25 ml). The organic layer was dried over Na2SO4, filtered off and the solvent removed in vacuo. The oily residue was dissolved in Et2O which crystallized slowly after a few days at 5 C; yield 3.2 g (62 %); mp 83-84 C; TLC: Rf (S1) = 0.79, Rf (S2) = 0.94; 1H NMR (CDCl3, delta ppm) 7.02 (d, J = 7.4 Hz, 2H, 3,5-Ph), 6.93 (m, 1H, 4-Ph), 4.46-4.23 (m, 2H, CH2-gamma), 4.01 (m, 1H, CH-alpha), 2.68 (m, 2H, CH2-beta), 2.40 (m, 6H, 2CH3, CH2-beta). ESI-MS (m/z) 206.0 [M+H]+. Anal. calcd for C12H15NO2: C, 70.22; H, 7.37; N, 6.82. Found: C, 69.69; H, 7.71; N, 6.84. According to 48 mp 85-86 C.
As the paragraph descriping shows that 5061-21-2 is playing an increasingly important role.
Reference£º
Article; Wieckowski, Krzysztof; Bytnar, Justyna; Bajda, Marek; Malawska, Barbara; Salat, Kinga; Filipek, Barbara; Stables, James P.; Bioorganic and medicinal chemistry; vol. 20; 21; (2012); p. 6533 – 6544,12;; ; Article; Wi?ckowski, Krzysztof; Sa?at, Kinga; Bytnar, Justyna; Bajda, Marek; Filipek, Barbara; Stables, James P.; Malawska, Barbara; Bioorganic and Medicinal Chemistry; vol. 20; 21; (2012); p. 6533 – 6544;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem