With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17347-61-4,2,2-Dimethylsuccinicanhydride,as a common compound, the synthetic route is as follows.
Synthesis of BA-derivatives 30, 35, 39-40, 45-48. A solution of the appropriate BA analog (1 eq), DMAP (1.5 eq) and the appropriate acid anhydride (5 eq) in anhydrous pyridine (1.5 mL) was stirred at 160 0C for 2 h using microwave (Biotage). The reaction mixture was diluted with EtOAc (15 mL) and washed three times with 20percent HCl solution and distilled water. The organic layer was dried over anhydrous Na2SO4 and concentrated to dryness under reduced pressure. The residue was chromatographed using a silica gel column to yield pure target compounds.
17347-61-4, 17347-61-4 2,2-Dimethylsuccinicanhydride 87067, aTetrahydrofurans compound, is more and more widely used in various fields.
Reference£º
Patent; THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL; DUKE UNIVERSITY; LEE, Kuo-Hsiung; QIAN, Keduo; YU, Donglei; CHEN, Chin-Ho; HUANG, Li; BORI, Ibrahim Danlami; WO2010/132334; (2010); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem