Day: October 19, 2020

42417-39-0, 3-Aminodihydrofuran-2(3H)-one hydrochloride is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,42417-39-0

The reactor was charged with 1 g of HSL ¡¤ HCl, 40 g of methanol and 0.05 g of Pt (5) / Ac, followed by NO / N2 (15 atm, 1: 1 (v / v) As above, additional H2 (6.5 atm) was added and the desmethylation reaction of HSL.HCl was performed. The product was partially recovered and the components were analyzed. The results are shown in Table 8 below.

42417-39-0 3-Aminodihydrofuran-2(3H)-one hydrochloride 445963, aTetrahydrofurans compound, is more and more widely used in various fields.

Reference£º
Patent; CJ CHEILJEDANG CORPORATION; KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY; YANG, YOUNG RYEOL; KIM, BYUNG SIK; KIM, JEONG HYUN; LEE, JUNG HO; SHIN, HYUN KWAN; KIM, JU NAM; CHO, KYUNG HO; (40 pag.)KR2015/118287; (2015); A;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5061-21-2,2-Bromo-4-butanolide,as a common compound, the synthetic route is as follows.

5061-21-2, To a solution of 8.5 ml toluene, 3.03 g (25 mmol) of 2,6-dimethylphenylamine and 4.12 (25 mmol) of 3-bromo-dihydrofuran-2(3H)-one, heated to 80 C, a solution of 1.73 g (12.5 mmol) of K2CO3 in 5 ml of water was added dropwise over 5 h. After cooling, the mixture was washed with 5% solution of KHCO3 (10 ml) and water (3 * 25 ml). The organic layer was dried over Na2SO4, filtered off and the solvent removed in vacuo. The oily residue was dissolved in Et2O which crystallized slowly after a few days at 5 C; yield 3.2 g (62 %); mp 83-84 C; TLC: Rf (S1) = 0.79, Rf (S2) = 0.94; 1H NMR (CDCl3, delta ppm) 7.02 (d, J = 7.4 Hz, 2H, 3,5-Ph), 6.93 (m, 1H, 4-Ph), 4.46-4.23 (m, 2H, CH2-gamma), 4.01 (m, 1H, CH-alpha), 2.68 (m, 2H, CH2-beta), 2.40 (m, 6H, 2CH3, CH2-beta). ESI-MS (m/z) 206.0 [M+H]+. Anal. calcd for C12H15NO2: C, 70.22; H, 7.37; N, 6.82. Found: C, 69.69; H, 7.71; N, 6.84. According to 48 mp 85-86 C.

As the paragraph descriping shows that 5061-21-2 is playing an increasingly important role.

Reference£º
Article; Wieckowski, Krzysztof; Bytnar, Justyna; Bajda, Marek; Malawska, Barbara; Salat, Kinga; Filipek, Barbara; Stables, James P.; Bioorganic and medicinal chemistry; vol. 20; 21; (2012); p. 6533 – 6544,12;; ; Article; Wi?ckowski, Krzysztof; Sa?at, Kinga; Bytnar, Justyna; Bajda, Marek; Filipek, Barbara; Stables, James P.; Malawska, Barbara; Bioorganic and Medicinal Chemistry; vol. 20; 21; (2012); p. 6533 – 6544;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17347-61-4,2,2-Dimethylsuccinicanhydride,as a common compound, the synthetic route is as follows.

To a stirred solution of ((1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-9- hydroxy-5a,5b,8,8,11a-pentamethyl-1-(1-methylcyclopropyl)icosahydro-1H-cyclopenta[a]chrysen-3a-yl)(piperidin-1-yl)methanone (step 2, 0.16 g, 0.29 mmol, 1.0 eq) in ethyl acetate (2 ml) 2,2-dimethylsuccinicanhydride (0.114 g, 0.89 mmol, 3.0 eq) and DMAP (0.109 g, 0.89 mmol, 3.0 eq) were added sequentially then refluxed at about 100 ¡ãC for overnight. After completion of the reaction monitored by TLC, the reaction mixture was cooled to 0 ¡ãC, acidified with 1.0 N citric acid solution, organic layer was separated and extracted with ethyl acetate (2×30 ml). The combined organic layers were washed with water, brine solution, dried over Na2S04, filtered, evaporated and purified by silicagel column chromatography using 10percent EtOAc: hexane as eluent to afford the title compound (50 mg, 25percent yield) as an off-white solid. 1H NMR (300 MHz, DMSO-d6): delta 12.1 (s, 1H), 4.37 (dd, 1H, J= 10.8, 4.8 Hz), 3.52-3.37 (m, 4H), 2.82-2.72 (m, 1H), 2.45-2.39 (m, 2H), 2.12-2.04 (m, 1H), 1.98-1.85 (m, 2H), 1.70-1.50 (m, 8H), 1.48-1.28 (m, 12H), 1.28-1.22 (m, 5H), 1.18-1.15 (m, 6H), 1.12-1.07 (m, 1H), 0.95 (s, 3H), 0.90-0.73 (m, 16H), 0.37-0.27 (m, 2H), 0.23-0.13 (m, 2H); Mass: [M+H]+ 666.5 (70percent); HPLC: 98.6percent., 17347-61-4

The synthetic route of 17347-61-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; HETERO RESEARCH FOUNDATION; PANDURANGA ADULLA, Reddy; PARTHASARADHI REDDY, Bandi; MANOHAR SHARMA, Vedula; RATHNAKAR REDDY, Kura; PREM KUMAR, Mamnoor; BHASKAR REDDY, Kasireddy; NARSINGAM, Mogili; VENKATI, Mukkera; VL SUBRAHMANYAM, Lanka; MALLIKARJUN REDDY, Ravi; WO2013/160810; (2013); A2;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.184950-35-4,(Tetrahydrofuran-3-yl)methanamine hydrochloride,as a common compound, the synthetic route is as follows.

5- [3- (2-naphthyl) propyl] isoxazole-3-carboxylic acid (0.56 g, 2.0 mmol) Tetrahydrofuran-3-ylmethylamine hydrochloride (0.33 g, 2.4 mmol), Triethylamine (0.25 g, 2.4 mmol) And 1-hydroxybenzotriazole (0.03 g, 0.24 mmol) Was added to chloroform (amylene added product) (5 mL). To the mixture, 1-Ethyl-3- (3-dimethylaminopropyl) carbodiimide hydrochloride (0.46 g, 2.4 mmol) was added at room temperature, After stirring overnight, And concentrated under reduced pressure. Dilute hydrochloric acid was added to the concentrate, Extracted twice with ethyl acetate. The organic layer was washed with saturated brine, After drying with anhydrous sodium sulfate, And concentrated under reduced pressure. The residue was subjected to silica gel column chromatography, Represented by the following equation N- (tetrahydrofuran-3-ylmethyl) -5- [3- (2-naphthyl) propyl] isoxazole-3-carboxamide (Hereinafter referred to as the present amide compound (228)) 0.49 g was obtained., 184950-35-4

The synthetic route of 184950-35-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SUMITOMO CHEMICAL COMPANY LIMITED; SUMITA, YUSUKE; (264 pag.)JP2015/51963; (2015); A;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17347-61-4,2,2-Dimethylsuccinicanhydride,as a common compound, the synthetic route is as follows.

General procedure: A mixture of the above intermediates (8, 9, 10 or 11), 2,2-dimethylsuccinic anhydride (10 equiv) and DMAP (1 equiv) in anhydrous pyridine (20 mL/mmol) was refluxed overnight. The mixture was then concentrated under vacuum and the residue was chromatographed on silica gel to yield the derivatives 12, 13, 14 and 15., 17347-61-4

As the paragraph descriping shows that 17347-61-4 is playing an increasingly important role.

Reference£º
Article; Coric, Pascale; Turcaud, Serge; Souquet, Florence; Briant, Laurence; Gay, Bernard; Royer, Jacques; Chazal, Nathalie; Bouaziz, Serge; European Journal of Medicinal Chemistry; vol. 62; (2013); p. 453 – 465;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17347-61-4,2,2-Dimethylsuccinicanhydride,as a common compound, the synthetic route is as follows.

To a chilled solution (ice/water bath) of bromobenzene (7.71 g, 49.1 mmol) and 3,3-dimethyldihydro-2,5-furandione (5.99 g, 46.7 mmol) in dichloroethane (150 mL) was added aluminum trichworide (13.28 g, 99.58 mmol). The ice bath was removed and the reaction mixture was stirred at rt overnight. The mixture was again chilled in an ice/water bath, and then quenched with 1 M aqueous hydrochloric acid. Water (70 mL) was added and the layers were separated. The aqueous layer was extracted with ethyl acetate (3.x.50 mL). The combined organic layers were dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The residue was purified by flash chromatography (Biotage apparatus, 17:83 ethyl acetate/hexane) to give 4-(4-bromophenyl)-2,2-dimethyl-4-oxobutanoic acid as a white solid (8.34 g, 63percent). LC-MS: ret. time 2.79 min; m/z 284.8 (MH+); 1H NMR (300 MHz, CDCl3) delta 1.36 (s, 6H), 3.27 (s, 2H), 7.60 (d, 2H), 7.81 (d, 2H).

17347-61-4, 17347-61-4 2,2-Dimethylsuccinicanhydride 87067, aTetrahydrofurans compound, is more and more widely used in various fields.

Reference£º
Patent; Bayer Pharmaceuticals Corporation; US2004/224997; (2004); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17347-61-4,2,2-Dimethylsuccinicanhydride,as a common compound, the synthetic route is as follows.

Synthesis of BA-derivatives 30, 35, 39-40, 45-48. A solution of the appropriate BA analog (1 eq), DMAP (1.5 eq) and the appropriate acid anhydride (5 eq) in anhydrous pyridine (1.5 mL) was stirred at 160 0C for 2 h using microwave (Biotage). The reaction mixture was diluted with EtOAc (15 mL) and washed three times with 20percent HCl solution and distilled water. The organic layer was dried over anhydrous Na2SO4 and concentrated to dryness under reduced pressure. The residue was chromatographed using a silica gel column to yield pure target compounds.

17347-61-4, 17347-61-4 2,2-Dimethylsuccinicanhydride 87067, aTetrahydrofurans compound, is more and more widely used in various fields.

Reference£º
Patent; THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL; DUKE UNIVERSITY; LEE, Kuo-Hsiung; QIAN, Keduo; YU, Donglei; CHEN, Chin-Ho; HUANG, Li; BORI, Ibrahim Danlami; WO2010/132334; (2010); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

696-59-3, 2,5-Dimethoxytetrahydrofuran is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

3-Chloroaniline (10.6 ml) and 2,5-dimethoxytetrahydrofuran (12.9 ml) are heated at 1 100C in acetic acid (100 ml) for 5 hours and 30 minutes. To the cooled reaction mixture, water (500 ml) is added and the reaction is stirred overnight. The brown precipitate formed is filtered and subsequently dissolved in dichloromethane, washed with aqueous sodium hydrogencarbonate (saturated) (1 00 ml), dried over sodium sulphate and concentrated in vacuo. 1-(3-Chloro-phenyl)-1 H-pyrrole is isolated as black solid (35.2 g). 1 H-NMR (400 MHz, CDCI3): 6.38 (t, 2H), 7.10 (t, 2H), 7.30 (m, 4H)., 696-59-3

696-59-3 2,5-Dimethoxytetrahydrofuran 79098, aTetrahydrofurans compound, is more and more widely used in various fields.

Reference£º
Patent; SYNGENTA PARTICIPATIONS AG; CORSI, Camilla; WENDEBORN, Sebastian Volker; BOBBIO, Carla; KESSABI, Jilali; SCHNEITER, Peter; GRASSO, Valeria; HAAS, Ulrich Johannes; WO2010/69879; (2010); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.19311-37-6,3-Bromotetrahydrofuran,as a common compound, the synthetic route is as follows.

To the saturated Na2S03 aqueous solution (20.0 mL) was added 3-bromotetrahydrofuran (2.00 g, 14.83 mmol). The mixture was heated to reflux and stirred for 24hand then concentrated in vacuo. The residue was stirred with EtOH (30 mL) at 50 oc for 30min, then filtered immediately. The filtrate was concentrated in vacuo and the residue was driedin vacuo to give the title compound as a white solid (1.81 g, yield 72.6%).MS (ESI, neg. ion) m/z: 151.1 [M-Nar;1H NMR (400 MHz, DMSO-d6) 8 (ppm): 3.80 (t, J = 8.6 Hz, 1H), 3.71-3.64 (m, 2H), 3.63-3.57(m, 1H), 3.20-3.11 (m, 1H), 2.02-1.87 (m, 2H).

19311-37-6, The synthetic route of 19311-37-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SUNSHINE LAKE PHARMA CO., LTD.; CALITOR SCIENCES, LLC; DAI, Weilong; XI, Ning; LI, Minxiong; ZHANG, Tao; LI, Xiaobo; HU, Haiyang; CHEN, Wuhong; WANG, Tingjin; LIU, Jun; (188 pag.)WO2017/48675; (2017); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

184950-35-4, (Tetrahydrofuran-3-yl)methanamine hydrochloride is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5- [3- (6-methoxy-2-naphthyl) propyl] isoxazole-3-carboxylic acid (0.62 g, 2.0 mmol) Tetrahydrofuran-3-ylmethylamine hydrochloride (0.41 g, 3.0 mmol), Triethylamine (0.30 g, 3.0 mmol) And 1-hydroxybenzotriazole (0.03 g, 0.2 mmol) Was added to chloroform (ammylene added product) (5 mL). To the mixture, 1-Ethyl-3- (3-dimethylaminopropyl) carbodiimide hydrochloride (0.46 g, 2.4 mmol) was added at room temperature, After stirring overnight, And concentrated under reduced pressure. Dilute hydrochloric acid was added to the residue, And extracted three times with ethyl acetate. The organic layer was washed with saturated aqueous sodium hydrogen carbonate solution, Washed with saturated brine, After drying with anhydrous sodium sulfate, And concentrated under reduced pressure. The residue was subjected to silica gel column chromatography, The following equation Indicated by N- (tetrahydrofuran-3-ylmethyl) -5- [3- (6-methoxy-2-naphthyl) propyl] isoxazole-3-carboxamide (Hereinafter referred to as the amide compound (247)) 0.48 g was obtained., 184950-35-4

184950-35-4 (Tetrahydrofuran-3-yl)methanamine hydrochloride 17750392, aTetrahydrofurans compound, is more and more widely used in various fields.

Reference£º
Patent; SUMITOMO CHEMICAL COMPANY LIMITED; SUMITA, YUSUKE; (264 pag.)JP2015/51963; (2015); A;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem