With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.88675-24-5,Tetrahydrofuran-3-amine,as a common compound, the synthetic route is as follows.
88675-24-5, General procedure: All reactions were carried out in vials under nitrogen atmosphere. Step 1: A solution of compound 15 (125?mumol, 1.0?equiv) and compound 16 (125?mumol, 1.0?equiv) in MeOH (0.3?M) was treated with NaHCO3 (250?mumol, 2.0?equiv) and stirred for 16?h at 30?¡ãC. The reaction was then treated with NaBH4 (125?mumol, 1.0?equiv) and stirred for 3?h (LCMS check). The reaction mixture was filtered and concentrated. The crude amine was suspended in 1?N NaOH (1?mL) and extracted with dichloromethane (3?¡Á?1?mL). The organics were pooled, dried (Na2SO4) and evacuated to afford 18. Step 2: A solution of 17 (75?mumol, 0.60?equiv) in DMF (0.1?M) was treated with HATU (75?mumol, 0.60?equiv) followed by the crude amine 18 (125?mumol, 1.0?equiv) and iPr2NEt (225?mumol, 1.8?equiv). The reactions were concentrated and purified directly by reversed phase preparative HPLC using a C18 column and eluting with acetonitrile?water (0.225percent formic acid or pH?=?10 NH4OH) gradient. All compounds were deemed greater than 95percent purity by LCMS and HPLC. #10;
The synthetic route of 88675-24-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Londregan, Allyn T.; Piotrowski, David W.; Futatsugi, Kentaro; Warmus, Joseph S.; Boehm, Markus; Carpino, Philip A.; Chin, Janice E.; Janssen, Ann M.; Roush, Nicole S.; Buxton, Joanne; Hinchey, Terri; Bioorganic and Medicinal Chemistry Letters; vol. 23; 5; (2013); p. 1407 – 1411;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem