With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.112372-15-3,Furo[2,3-c]pyridine-2-carboxylic acid,as a common compound, the synthetic route is as follows.
112372-15-3, A solution of 4-(piperidine-1-sulfonyl)-benzylamine (500 mg, 1.93 mmol, 1 .00 equiv, furo[2,3-c]pyridine-2-carboxylic acid (355 mg, 2.13 mmol, 1 .1 1 equiv), DIPEA (762 mg, 5,79 mmol, 3.00 equiv), and benzotriazol-1- yloxytris(dimethylamino)phosphonium hexafluorophosphate (1044 mg, 2.31 mmol, 1 .20 equiv) in DMF (5 mL) was stirred overnight at rt. The reaction was quenched by the addition of 20 mL of water. The precipitated product was collected by filtration and re-crystallized from ethanol to give 304 8 mg (40%) of the title compound as a light brown solid. NMR (300 MHz, DMSO-d6 delta 9.67-9 63 (t, J = 6 Hz, 1 H), 9.06 (s, 1 H), 8.49-8.48 (d, – 3 Hz, 1 H), 7.84-7.83 (t, ./ = 3 Hz, 1 H), 7.71 -7.69 (d, .7 = 4 Hz, 3H), 7.59-7.57 (d, J = 6 Hz, 2H), 4.60 (d, J = 6.3 Hz, 2H), 2.89-2.84 (m, 4H), 1.61 – 1 .50 (m, 4H), 1.36- 1 .34 (m, 2H). LC/MS (Method H, ESI): RT = 1 .20 min, m/z = 400.0 [M + H]
As the paragraph descriping shows that 112372-15-3 is playing an increasingly important role.
Reference£º
Patent; GENENTECH, INC.; FORMA TM, LLC; BAIR, Kenneth W.; BAUMEISTER, Timm R.; BUCKMELTER, Alexandre J.; CLODFELTER, Karl H.; DRAGOVICH, Peter; GOSSELIN, Francis; GUNZNER-TOSTE, Janet; HAN, Bingsong; LIN, Jian; LIU, Xiongcai; REYNOLDS, Dominic J.; SMITH, Chase C.; WANG, Zhongguo; ZAK, Mark; ZHANG, Yamin; ZHAO, Guiling; ZHENG, Xiaozhang; YUEN, Po-Wai; WO2013/127266; (2013); A1;,
Tetrahydrofuran – Wikipedia
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