With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.184950-35-4,(Tetrahydrofuran-3-yl)methanamine hydrochloride,as a common compound, the synthetic route is as follows.
5- (1,1-difluoro-1-phenylmethyl) isoxazole-3-carboxylic acid chloride ( Was added tetrahydrofuran-3-ylmethylamine hydrochloride (200 mg, 1.45 mmol) in toluene solution (10 mL) And 1 mol / L sodium hydroxide aqueous solution (10 mL) were simultaneously added under cooling with ice water. After vigorously stirring for 1 hour under cooling with ice water, The reaction mixture was extracted twice with ethyl acetate. The organic layer was washed with saturated brine, After drying with anhydrous sodium sulfate, And concentrated under reduced pressure. The residue was subjected to silica gel column chromatography, Represented by the following equation N- (tetrahydrofuran-3-ylmethyl) -5- (1,1-difluoro-1-phenylmethyl) isoxazole-3-carboxamide (Hereinafter referred to as the present amide compound (155)) 190 mg., 184950-35-4
The synthetic route of 184950-35-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; SUMITOMO CHEMICAL COMPANY LIMITED; SUMITA, YUSUKE; (264 pag.)JP2015/51963; (2015); A;,
Tetrahydrofuran – Wikipedia
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