With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17347-61-4,2,2-Dimethylsuccinicanhydride,as a common compound, the synthetic route is as follows.
Step F: Compound 19-1 To a solution of the intermediate 18-1 (70 mg, 0.13 mmol) in pyridine (3 mL) were added 3,3-dimethyldihydro-2, 5-furandione (159 mg, 1.302 mmol) and DMAP (334 mg, 2.6 mmol). After it was heated at 90 ¡ãC overnight, the reaction mixture was extracted with DCM. The organic phase was washed with HC1 (2 N, 25 mL), water (50 mL x 2), dried over sodium sulfate, and evaporated under reduced pressure to give a residue, which was purified by column chromatography on silica gel (PE:EtOAc = 3: 1 to 2: 1) to give the compound 19-1 (30 mg, 34.6 percent) as a white solid product. 1H NMR (400 MHz, CDC13) delta ppm 4.54-4.42 (2H, m), 4.28-4.35 (1H, m), 4.05-4.15 (2H, m), 3.17-3.25 (1H, m), 2.75- 2.62 (4H, m), 2.60-2.52 (2H, m), 2.35(1H, quint, J= 8.0 Hz), 2.17 (1H, d, J= 19.2 Hz), 2.10-2.00 (1H, m), 1.96-1.82 (1H, m), 1.78-0.78 (42H, m). LC/MS: m/z calculated 665.9, found 664.4 (M – 1)-., 17347-61-4
The synthetic route of 17347-61-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; GLAXOSMITHKLINE LLC; GAO, Daxin; HAN, Nianhe; JIN, Zhimin; NING, Fangxian; TANG, Jun; WU, Yongyong; YANG, Heping; WO2011/100308; (2011); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem