With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.184950-35-4,(Tetrahydrofuran-3-yl)methanamine hydrochloride,as a common compound, the synthetic route is as follows.
5- (3-trifluoromethylbenzyl) isoxazole-3-carboxylic acid (242 mg, 0.89 mmol), Tetrahydrofuran-3-ylmethylamine hydrochloride (155 mg, 1.15 mmol), Triethylamine (0.32 mL, 2.30 mmol) And 1 – hydroxybenzotriazole (15 mg, 0.11 mmol) Was added to chloroform (amylen added product) (5 mL). To the mixture, 1-Ethyl-3- (3-dimethylaminopropyl) carbodiimide hydrochloride (220 mg, 1.15 mmol) was added at room temperature, After stirring overnight, it was concentrated under reduced pressure. The residue was subjected to silica gel column chromatography, Represented by the following equation N- (tetrahydrofuran-3-ylmethyl) -5- (3-trifluoromethylbenzyl) isoxazole-3-carboxamide (Hereinafter referred to as the amide compound (158)) 130 mg was obtained., 184950-35-4
The synthetic route of 184950-35-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; SUMITOMO CHEMICAL COMPANY LIMITED; SUMITA, YUSUKE; (264 pag.)JP2015/51963; (2015); A;,
Tetrahydrofuran – Wikipedia
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