184950-35-4, (Tetrahydrofuran-3-yl)methanamine hydrochloride is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Production Example 151 (0471) 5-(Naphthalen-2-ylmethyl)isoxazole-3-carboxylic acid (204 mg, 0.81 mmol), tetrahydrofuran-3-ylmethylamine hydrochloride (204 mg, 1.48mmol), triethylamine (0.38 mL, 2.75 mmol) and 1-hydroxybenzotriazole (14 mg, 0.11 mmol) were added to chloroform (amylene addition product) (5 mL). 1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (264 mg, 1.38 mmol) was added to the mixture at room temperature, and the mixture was stirred overnight and then concentrated under reduced pressure. The residue was applied to a silica gel column chromatography to obtain 166 mg of N-(tetrahydrofuran-3-ylmethyl)-5-(naphthalen-2-ylmethyl)iso xazole-3-carboxamide (hereinafter, referred to as Compound of Present Invention (159)) represented by the following formula. 1H-NMR (CDCl3, TMS, delta(ppm)):1.60-1.72(m, 1H), 2.02-2.12(m, 1H), 2.52-2.61(m, 1H), 3.41-3.46(m, 2H), 3.57(dd, J=9.0, 5.3Hz, 1H), 3.72-3.79(m, 1H), 3.82-3.93(m, 2H), 4.29(s, 2H), 6.43(d, J=3. 9Hz, 1H), 6.90(brs, 1H), 7. 34-7. 38 (m, 1H), 7. 46-7. 53 (m, 2H), 7.71(s, 1H), 7.78-7.86(m, 3H)
184950-35-4, 184950-35-4 (Tetrahydrofuran-3-yl)methanamine hydrochloride 17750392, aTetrahydrofurans compound, is more and more widely used in various fields.
Reference£º
Patent; Sumitomo Chemical Company, Limited; MITSUDERA, Hiromasa; AWASAGUCHI, Kenichiro; AWANO, Tomotsugu; UJIHARA, Kazuya; EP2952096; (2015); A1;,
Tetrahydrofuran – Wikipedia
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