Month: September 2020

22929-52-8, Dihydrofuran-3(2H)-one is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Intermediate 164 Ethyl 3-[[(trans-4-methylcyclohexyl)carbonyl](tetrahydro-3-furanyl)amino]-1- (phenylmethyl)-1 ate To a solution of Intermediate 163 (3.73 g, 11.8 mmol) in DCM (35 mL) was added trans-4- methylcyclohexanecarbonyl chloride (2.28 g, 14 mmol), followed by triethylamine (2.5 mL). The reaction was heated at 45 ¡ãC for 16 hours under nitrogen, whereupon further aliquots of triethylamine (2 mL) and trans-4-methylcyclohexanecarbonyl chloride (1.5 g) were added. Heating was continued for a further 16 hours. After cooling, the mixture was diluted with DCM, washed with hydrochloric acid solution (1M), then water, and then saturated sodium bicarbonate solution. The organic layer was passed through a hydrophobic frit, evaporated, and purified using 120 g ISCO Flash column, eluting with a gradient of ethyl acetate in cyclohexane (5-100percent) to give the title compound. MS calcd for (C25H33N304+ H) + : 440 MS found (electrospray) : (M+H) += 440

22929-52-8, As the paragraph descriping shows that 22929-52-8 is playing an increasingly important role.

Reference£º
Patent; GLAXO GROUP LIMITED; WO2005/92863; (2005); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

5061-21-2, 2-Bromo-4-butanolide is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5061-21-2, [Example 1]; Production of 2-mercapto-4-butyrolactone; 49 g (0.6 mol) of 70% sodium hydrosulfide (manufactured by JUNSEI CHEMICAL Co., Ltd.) were dissolved in a mixture of 34 g of 1,2-dimethoxyethane (Guaranteed Reagent; manufactured by JUNSEI CHEMICAL CO., LTD.) and 34 g of purified water (which had been distilled and passed through an ion exchange filter) at room temperature. While the resultant solution was cooledwith ice (to 100C or less) and under normal pressure (about 0.10MPa), 18 g of hydrochloric acid (GUARANTEED REAGENT, 35%to 37%; manufactured by JUNSEI CHEMICAL Co., Ltd.) were addedwith stirring the solution to adjust the pH of the solution to8.9. While the solution was maintained at a temperature of 100C or less, 34 g (0.2 mol) of 2-bromo-4-butyrolactone (manufacturedby Tokyo Chemical Industry Co., Ltd.) were added dropwise intothe solution over approximately 20 minutes. The reaction solution after the completion of the dropwise addition was stirred for 2 minutes . The pH of the reaction solution was withinthe range of 7.5 to 8.9 from when the dropwise addition of 2-bromo-4-butyrolactone was initiated to the stirring after thedropwise addition was completed. [0077]Thereafter, while the solution was cooled at 100C or less, 24 g of hydrochloric acid were added to the solution overapproximately 5 minutes to adjust the pH of the solution to 4.0. An inorganic salt precipitated in the solution was removed by suction filtration, and 20 g of ethyl acetate (GUARANTEED REAGENT; manufactured by JUNSEI CHEMICAL Co., Ltd.) were added to the resultant filtrate to extract the organic phase. The resultant aqueous phase was reextracted with 34 g of ethyl acetate. These extracted organic phases were combined. The organic phase was concentrated and purified by distillationunder a reduced pressure to give 19 g of2-mercapto-4-butyrolactone (having a boiling point of 94C/0.3 kPa; with a yield of 78%) .; [Examples 33 to 36]; In substantially the same manner as in Example 1 except that the temperature of the reaction solution during the reaction was changed as described in Table 4, the reaction was performed to synthesize 2-mercapto-4-butyrolactone. The results are shown in Table 4. The SH reaction yields in Table4 were calculated from the HPLC analysis results of samples which had been picked up from the reaction solution when the pH of the reaction solution was adjusted to 4.0.

5061-21-2 2-Bromo-4-butanolide 95463, aTetrahydrofurans compound, is more and more widely used in various fields.

Reference£º
Patent; SHOWA DENKO K.K.; WO2007/139215; (2007); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

97-99-4, (Tetrahydrofuran-2-yl)methanol is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The mixture of triethylamine (6.4 mL, 45.53 mmol), TsCI (6.4 g, 33.39 mmol) and 1 85 mg of DMAP were combined in CH2CI2 (70 mL). this solution was cooled in an ice bath and to it was added a solution of tetrahydrofurfuryl alcohol 164a (3.1 g, 30.35 mmol) in 30 mL of CH2CI2 over 20 min. the reaction stirred overnight and was then concentrated in vacuum, the residue was taken up in ethyl acetate and then washed 2 times with a saturated solution of NaHC03 and once with a brine. The organic layers were dried over MgS04, filtered and concentrated in vacu u m . The cru de prod u ct was pu rified by Col u m n ch romatography on si l ica gel (CH2CI2/CyHex: 50/50) to give the expected product as oil (m = 5.6 g, 72 %). 1H NMR (300 MHz, CDCIs) delta 1 .48-1 .68 (m, 1 H), 1 .71 -2.05 (m, 3H), 2.40 (s, 3H), 3.58-3.82 (m, 2H), 3.86-4.15 (m, 3H), 7.31 (d, J = 8.0 Hz, 2H), 7.75 (d, J = 8.2 Hz, 2H). MS [M+H]+ 257 g/mol., 97-99-4

The synthetic route of 97-99-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; UNIVERSITE DE LILLE 2 DROIT ET SANTE; INSTITUT PASTEUR DE LILLE; INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE); CHARTON, Julie; DEPREZ, Benoit; LEROUX, Florence; STAELS, Bart; MUHR-TAILLEUX, Anne; HENNUYER, Nathalie; LESTAVEL, Sophie; PICON, Sylvain; AKNIN, Karen; BOULAHJAR, Rajaa; DUBANCHET, Barbara; (234 pag.)WO2016/16238; (2016); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.184950-35-4,(Tetrahydrofuran-3-yl)methanamine hydrochloride,as a common compound, the synthetic route is as follows.

184950-35-4, 5- [4-benzyloxybutyl] isoxazole-3-carboxylic acid (0.42 g, 1.5 mmol), Tetrahydrofuran-3-ylmethylamine hydrochloride (0.26 g, 1.9 mmol), Triethylamine (0.19 g, 1.9 mmol) And 1-hydroxybenzotriazole (0.03 g, 0.19 mmol) Was added to chloroform (amylene added product) (3 mL). To the mixture , 1-ethyl-3- (3-dimethylaminopropyl) carbodiimide hydrochloride (0.37 g, 1.9 mmol) was added at room temperature, After stirring overnight, And concentrated under reduced pressure. Dilute hydrochloric acid was added to the concentrate, Extracted twice with ethyl acetate. The organic layer was washed with saturated brine, After drying with anhydrous sodium sulfate, And concentrated under reduced pressure. The residue was subjected to silica gel column chromatography, The following equation Indicated by N- (tetrahydrofuran-3-ylmethyl) -5- [4-benzyloxybutyl] isoxazole-3-carboxamide (Hereinafter referred to as present amide compound (140)) 0.62 g was obtained.

The synthetic route of 184950-35-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SUMITOMO CHEMICAL COMPANY LIMITED; SUMITA, YUSUKE; (264 pag.)JP2015/51963; (2015); A;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

87392-05-0, (R)-(+)-2-Tetrahydrofuroic acid is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

6.01.17 R-(tetrahydrofuran-2-yl)-methanol 20 g R-tetrahydrofuran-2-carboxylic acid in 60 mL THF was dropped to 6.6 g lithium aluminium hydride in 140 mL THF. The reaction was refluxed until gas formation was stopped. The reaction was coolded with an ice bath and 20 mL water and 10 mL 15N sodiunhydroxide was added. The reaction was stirred 20 min, diluted with 100 mL THF, filltered over magnesiumsulfate and the filtrate was evaporated to give 16.1 g desired product. (M+Na)+: 124 1H-NMR (400 MHZ): 4.6 (1H OH), 3.8; 3.6; 3.3 (5H, CH2, CH, CH2); 1.8; 1.55 (m, 4H, CH2, CH2)., 87392-05-0

As the paragraph descriping shows that 87392-05-0 is playing an increasingly important role.

Reference£º
Patent; Boehringer Ingelheim International GmbH; GRAUERT, Matthias; BISCHOFF, Daniel; DAHMANN, Georg; KUELZER, Raimund; RUDOLF, Klaus; US2013/184248; (2013); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

2399-48-6, (Tetrahydrofuran-2-yl)methyl acrylate is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Under an argon atmosphere, tetrahydrofurfuryl acrylate (manufactured byTokyo Kasei Kogyo Co., Ltd.) 10.0 g (64 mmol) of 3-mercaptopropyltrimethoxysilane (Shin-Etsu Chemical Co., Ltd.) 12.5 g (64 mmol) and azobisbutyronitrile (manufactured by Nacalai Tesque) 210 mg (1.2 mmol) were dissolvedin dehydrated ethyl acetate 60 ml, was heated under reflux for 24 hours. Underreduced pressure to remove ethyl acetate, the No2-8 compound is a compound ofthe present invention was obtained 21.8 g.

2399-48-6, 2399-48-6 (Tetrahydrofuran-2-yl)methyl acrylate 94232, aTetrahydrofurans compound, is more and more widely used in various fields.

Reference£º
Patent; KRI INCORPORATED; SATOH, MASAHIRO; KITAJIMA, SATSUKI; (23 pag.)JP2015/218139; (2015); A;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

204512-95-8, (S)-Tetrahydrofuran-3-amine hydrochloride is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

). (c) l-(5,6-Dimethyl-l-p-tolyl-lH-benzo[d]imidazol-2-yl)piperidine-4-carboxylic acid (37 mg, 0.10 mmol), 2-(7-aza-lH-benzotriazole-l-yl)-l,l,3,3-tetramethyluronium hexafluorophosphate (EtaATU, 58 mg, 0.153 mmol), (S)-tetrahydrofuran-3 -amine hydrochloride (18.9 mg, 0.153 mmol) and iV,jV-diisopropyl-ethylamine (Etaunig’s base, DIEA, 170 muL, 1.02 mmol) were dissolved in N,N-dimethylformamide (1 mL). The reaction mixture was stirred overnight at ambient temperature, filtered and subjected to preparative hplc (preparative RP-LC was performed on a Gilson system equipped with a Zorbax SB-C8 (5 mum, 21.2 x 150 mm) column, using methano I/water (0.05% formic acid) gradients at a flow rate of 4 mL/min with UV (214 or 254 nm) and MS (ESI) detection) to give 33 mg (75 % yield) of (S)-l-(5,6-dimethyl-l-p-tolyl- lH-benzo[d]imidazol-2-yl)-N-(tetrahydrofuran-3-yl)piperidine-4-carboxamide as an off-white solid. LC-MS (m/z) 433.0. (M+l).

204512-95-8, As the paragraph descriping shows that 204512-95-8 is playing an increasingly important role.

Reference£º
Patent; NOVASAID AB; WANNBERG, Johan; ALTERMAN, Mathias; MALM, Johan; STENBERG, Patric; WESTMAN, Jacob; WALLBERG, Hans; WO2011/23812; (2011); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

112372-15-3, Furo[2,3-c]pyridine-2-carboxylic acid is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Coupling: Example 7 is obtained as a white solid with a yield of 18% using acid C34 according to Method A with non-critical changes. HRMS (FAB) calculated for C15H17N3O2+H: 272.1399, found 272.1402 (M+H)+., 112372-15-3

As the paragraph descriping shows that 112372-15-3 is playing an increasingly important role.

Reference£º
Patent; Wishka, Donn G.; Reitz, Steven Charles; Piotrowski, David W.; Groppi JR., Vincent E.; US2003/45540; (2003); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

111769-27-8, (R)-Tetrahydrofuran-3-amine 4-methylbenzenesulfonate is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

4-(3-Cyclopropylmethyl-6,6-dimethyl-4-oxo-4,5,6,7-tetrahydroindazol-1-yl)-2,5-difluorobenzonitrile (95 mg, 0.27 mmol), R-(+)-3-aminotetrahydrofuran toluene-4-sulfonate (70 mg, 0.27 mmol), and diisopropylamine (0.1 mL, 0.6 mmol) were combined in DMSO (0.5 mL). The reaction was stirred at 100 C. for 48 hours and then cooled to 25 C., and EtOH (2 mL), 1 M NaOH (0.4 mL), and 30% aqueous H2O2 (0.4 mL) were added. The reaction was stirred at 25 C. for 1 hour. It was diluted with EtOAc (20 mL), and washed with 2 M HCl (2¡Á20 mL). The organic portion was dried over Na2SO4 and concentrated. Purification by gradient flash chromatography provided (R)-4-(3-(cyclopropylmethyl)-6,6-dimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indazol-1-yl)-5-fluoro-2-(tetrahydrofuran-3-ylamino)benzamide (43 mg, 36%) as a yellow solid (LC/MS m/z=441.1 [M+H]+). 1H NMR (DMSO, 20 C., 400 MHz) delta (ppm) 8.13 (d, 1H), 7.87 (b, 1H), 7.59 (d, 1H), 7.32 (b, 1H), 6.61 (d, 1H), 3.98-3.91 (m, 1H), 3.70-3.60 (m, 2H), 3.59-3.51 (m, 1H), 3.37-3.30 (m, 1H), 2.54 (d, 2H), 2.50 (s, 2H), 2.16 (s, 2H), 2.10-1.99 (m, 1H), 1.58-1.50 (m, 1H), 1.00-0.90 (m, 1H), 0.83 (s, 6H), 0.24-0.18 (m, 2H), 0.03-0.02 (m, 2H)., 111769-27-8

The synthetic route of 111769-27-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Huang, Kenneth He; Ommen, Andy J.; Barta, Thomas E.; Hughes, Philip F.; Veal, James; Ma, Wei; Smith, Emilie D.; Woodward, Angela R.; McCall, W. Stephen; US2008/269193; (2008); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

219823-47-9, (R)-Tetrahydrofuran-3-yl 4-methylbenzenesulfonate is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A suspension of 3-hydroxy-N-(l-methyl-lH-pyrazol-3-yl)-5- [(phenylmethyl)oxy]benzamide (450 mg, 1.39 mmol), (3i?)-tetrahydrofuran-3-yl 4- methylbenzenesulfonate (507 mg, 2.09 mmol) and potassium carbonate (481 mg, 3.48 mmol) in acetonitrile (5 mL) was stirred in a Smith Creator microwave at 16O0C for 3 hours. The solvent was removed in vacuo and ethyl acetate added. The organics were washed with water (40 mL), brine (40 mL), dried (MgSO4), filtered and the solvent removed in vacuo to give a yellow foam which was chromatographed on silica, eluting with a gradient of 0-100% ethyl acetate in o-hexane, to give the title compound as a white foam (452 mg). 1H NuMR delta (CDCl3): 2.09 – 2.14 (IH, m), 2.14 – 2.24 (IH, m), 3.68 (3H5 s), 3.86 – 3.91 (IH, m), 3.94 – 3.98 (3H, m), 4.89 (IH, s), 5.03 (2H, s), 6.64 (IH, t), 6.85 (IH, s), 6.96 (IH, d), 7.07 (IH, t), 7.27 (IH, m), 7.33 – 7.41 (5H, m), 9.31 (IH, s); m/z 394 (M+H)+., 219823-47-9

As the paragraph descriping shows that 219823-47-9 is playing an increasingly important role.

Reference£º
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2006/125972; (2006); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem