10374-51-3, 5-(Hydroxymethyl)dihydrofuran-2(3H)-one is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
10374-51-3, (3) at room temperature,To a 500 mL four-necked flask was added 15 g of compound 3,14.4 g of TEA and 150 mL of DCM.Nitrogen replacement three times, nitrogen protection,Cooling to -30 ,16.3 g of methanesulfonyl chloride (MsCl) was slowly added to the system,Warming significantly, temperature control -40 drop.After 10 min, the drop was completed and the incubation reaction was carried out for 10 min.After returning to room temperature reaction.To the system by adding 200mL of water quenching, the system directly liquid,The aqueous phase was extracted with DCM (50 mL * 3), the organic phases were combined, dried,The water was concentrated to give a total of 27.5 g of a brown oily liquid (Compound 4).
10374-51-3 5-(Hydroxymethyl)dihydrofuran-2(3H)-one 98431, aTetrahydrofurans compound, is more and more widely used in various fields.
Reference£º
Patent; Si Fenke Si Pharmaceutical Research And Development (Tianjin) Co., Ltd.; Yao Qingjia; Wu Simin; Xu Yangjun; (6 pag.)CN106748972; (2017); A;,
Tetrahydrofuran – Wikipedia
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