Brief introduction of 88675-24-5

The synthetic route of 88675-24-5 has been constantly updated, and we look forward to future research findings.

88675-24-5, Tetrahydrofuran-3-amine is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

In a dry flask was placed 8-am ino-6-(3-fluorophenyl)-5-[2-methyl-6-(trifluoromethyl) pyrid in-4- yl]imidazo[i ,2-a]pyrazine-2-carboxylic acid (example 76) (30 mg, 0.07 mmol) then DMF (2 mL) was added and to this HATU (31 mg, 0.08 mmol, 1.2 equiv.) was added. Reaction mixture was stirred for 10 minutes and then DIPEA (0.04 mL, 0.21 mmol, 3 equiv.) followed by 3-aminotetra-hydrofuran (0.06 mg, 0.07 mmol, 1 equiv.) were added and reaction was stirred at r.t. for 48h. Reaction mixture was concentrated under reduced pressure and purified by using flash chromatography (silica gel, DCM/MeOH 0percent to 10percent) to lead to the title compound as a off-white solid, hydrochloride salt (10 mg, 29percent). ESI-MS: 501.20 [M+H]+. 1H NMR (400 MHz, DMSO-d6) 6 8.20 (d, J = 7.2 Hz, 1 H), 8.05 (s, 1 H), 7,88 (s, 2H), 7.76 (s, 1 H), 7.62 (s, 1 H), 7.35 ? 7.25 (m,1 H), 7.20 ?7.11 (m, 2H), 7.08?7.00 (m, 1 H), 4.54 ?4.42 (m, 1 H), 3.91 ?3.79 (m, 2H), 3.75?3.68 (m, 2H), 2.58 (s, 3H), 2.25?2.15 (m, 1 H), 1.95?1.85 (m, 1 H)., 88675-24-5

The synthetic route of 88675-24-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SELVITA S.A.; BOBOWSKA (NEE WITKOWSKA), Aneta; GALEZOWSKI, Michal; NOWAK, Mateusz; COMMANDEUR, Claude; SZEREMETA-SPISAK, Joanna; NOWOGRODZKI, Marcin; OBARA, Alicja; DZIELAK, Anna; LOZINSKA, Iwona; DUDEK (NEE SEDLAK), Marcelina; JANIGA, Anita; REUS, Jacek; WRONOWSKI, Marek; ZASTAWNA, Magdalena; RADZIMIERSKI, Adam; SWIRSKI, Mateusz; ZACHMANN, Julian; FABRITIUS, Charles-Henry; PORTER, Rod; FOGT, Joanna; (276 pag.)WO2019/2606; (2019); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem