16874-34-3, Ethyl tetrahydrofuran-2-carboxylate is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A flask was charged with 13.6 g of magnesium and 300 ml of tetrahydrofuran, to which 60.3 g of 1,4-dibromobutane was added dropwise at 50 C. After the completion of dropwise addition, the solution was stirred at 60 C. for one hour.To the solution below 40 C., 31.0 g of ethyl tetrahydrofurancarboxylate was added dropwise.The solution was stirred at room temperature for one hour, after which an aqueous solution of ammonium chloride was added for hydrolysis.Ordinary post-treatment yielded 30.2 g of 1-(2-tetrahydrofuranyl)cyclopentanol. In 80 ml of toluene were dissolved 16.8 g of 1-(2-tetrahydrofuranyl)cyclopentanol, 13.1 g of triethylamine, and 0.5 g of 4-(N,N-dimethylamino)pyridine. Then 10.7 g of acrylic chloride was added to the solution at 50 C., which was stirred at the temperature for one hour. Water, 50 ml, was added to the solution below 30 C., followed by ordinary post-treatment. Vacuum distillation yielded 18.1 g of 1-(2-tetrahydrofuranyl)cyclopentyl acrylate. The two-step yield was 80%. [0583] boiling point: 84-86 C./86 Pa [0584] IR (thin film): nu=2954, 2871, 1720, 1635, 1619, 1450, 1402, 1298, 1207, 1170, 1074, 1049, 983, 811 cm-1 [0585] 1H-NMR (300 MHz in CDCl3): delta=1.49-2.25 (12H, m), 3.70-3.92 (2H, m), 4.57 (1H, t), 5.72 (1H, dd), 6.04 (1H, dd), 6.29 (1H, dd) ppm, 16874-34-3
The synthetic route of 16874-34-3 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Hasegawa, Koji; Kinsho, Takeshi; Watanabe, Takeru; US2004/68124; (2004); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem