With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4100-80-5,3-Methyldihydrofuran-2,5-dione,as a common compound, the synthetic route is as follows.
Add methylsuccinic anhydride (5g, 43.8 mmole) to a stirred suspension of 1,3- difluorobenzene (25g, 219.1 mmole) and aluminum chloride (11.7g, 87.6 mmole), keeping the temperature less than 50¡ãC. Stir the reaction overnight at 50¡ãC and then for 3 days at 78¡ãC. Cool to room temperature and slowly add reaction mixture to a mixture of 3N HCI (40 mL) and ice (40g). Add methylene chloride (80 mL) and separate the organic layer, then extract the aqueous phase with additional methylene chloride (70 mL). Wash the combined organic phase twice with 1 N NaOH solution (80 mL) and then acidify the combined basic wash with 6N HCI. Extract the acidic aqueous phase twice with methylene chloride (100 mL), dry over Na2SO4 and concentrate to obtain product. ESMS 229, tR (min) = 1.57. 1H-NMRshowed a 4: 1 mixture of isomeric products.
4100-80-5, 4100-80-5 3-Methyldihydrofuran-2,5-dione 20051, aTetrahydrofurans compound, is more and more widely used in various fields.
Reference£º
Patent; AVENTIS PHARMACEUTICALS INC.; WO2005/111025; (2005); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem