184950-35-4, (Tetrahydrofuran-3-yl)methanamine hydrochloride is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Production Example 141 (0461) 5-(6-Phenoxyhexyl)isoxazole-3-carboxylic acid (0.72 g, 2.5 mmol), tetrahydrofuran-3-ylmethylamine hydrochloride (0.42 g, 3.0 mmol), triethylamine (0.31 g, 3.0 mmol) and 1-hydroxybenzotriazole (0.04 g, 0.30 mmol) were added to chloroform (amylene addition product) (8 mL). 1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (0.58 g, 2. mmol) was added to the mixture at room temperature, and the mixture was stirred overnight and then concentrated under reduced pressure. Dilute hydrochloric acid was added to the concentrate, and the mixture was extracted twice with ethyl acetate. The organic layer was washed with saturated saline water, dried over anhydrous sodium sulfate, and then concentrated under reduced pressure. The residue was applied to a silica gel column chromatography to obtain 0.77 g of N-(tetrahydrofuran-3-ylmethyl)-5-(6-phenoxyhexyl)isoxazole-3-carboxamide (hereinafter, referred to as Compound of Present Invention (148)) represented by the following formula. 1H-NMR(CDCl3, TMS, delta(ppm)):1.40-1.56(4H, m), 1.64-1.68(1H, m), 1.72-1.82(4H, m), 2.04-2.13(1H, m), 2.52-2.62(1H, m), 2.81(2H, t), 3.46(2H, dt), 3.58(1H, dd), 3.73-3.79(1H, m), 3.86(1H, dd), 3.88-3.93(1H, m), 3.95(2H, t), 6.45(1H, s), 6.87-6.95(4H, m), 7.27-7.29(2H, m)
184950-35-4, 184950-35-4 (Tetrahydrofuran-3-yl)methanamine hydrochloride 17750392, aTetrahydrofurans compound, is more and more widely used in various fields.
Reference£º
Patent; Sumitomo Chemical Company, Limited; MITSUDERA, Hiromasa; AWASAGUCHI, Kenichiro; AWANO, Tomotsugu; UJIHARA, Kazuya; EP2952096; (2015); A1;,
Tetrahydrofuran – Wikipedia
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