With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.184950-35-4,(Tetrahydrofuran-3-yl)methanamine hydrochloride,as a common compound, the synthetic route is as follows.
Production Example 127 (0443) Tetrahydrofuran-3-ylmethylamine hydrochloride (0.45 g, 3.26 mmol) and triethylamine (0.33 g, 3.26 mmol) were added to chloroform (amylene addition product) (13 mL). 5-(2-Cyclopentylethyl)oxymethylisoxazole-3-carboxylic acid (0. 65 g, 2.72 mmol), 1-hydroxybenzotriazole (0.04 g, 0.27 mmol) and 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (0.63 g, 3.26 mmol) were added to the mixture at room temperature, and the mixture was stirred overnight. Then, dilute hydrochloric acid was added thereto, and the mixture was extracted twice with chloroform. The organic layer was washed with a saturated aqueous sodium bicarbonate solution, dried over anhydrous sodium sulfate, and then concentrated under reduced pressure. The residue was applied to a silica gel column chromatography to obtain 0.85 g of N-(tetrahydrofuran-3-ylmethyl)-5-(2-cyclopentylethyl)oxymet hylisoxazole-3-carboxamide (hereinafter, referred to as Compound of Present Invention (132)) represented by the following formula. 1H-NMR(CDCl3, TMS, delta(ppm)):1.05-1.13(2H, m), 1.46-1.90(10H, m), 2.05-2.13(1H, m), 2.53-2.63(1H, m), 3.45-3.48(2H, m), 3.52-3.56(2H, m), 3.57-3.61(1H, m), 3.74-3.80(1H, m), 3.84-3.94(2H, m), 4.61(2H, s), 6.70(1H, s), 6.94(1H, br s), 184950-35-4
184950-35-4 (Tetrahydrofuran-3-yl)methanamine hydrochloride 17750392, aTetrahydrofurans compound, is more and more widely used in various fields.
Reference£º
Patent; Sumitomo Chemical Company, Limited; MITSUDERA, Hiromasa; AWASAGUCHI, Kenichiro; AWANO, Tomotsugu; UJIHARA, Kazuya; EP2952096; (2015); A1;,
Tetrahydrofuran – Wikipedia
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