With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.118399-28-3,(R)-Benzyl (5-oxotetrahydrofuran-3-yl)carbamate,as a common compound, the synthetic route is as follows.
Compound 0101 (24 g, 0.1 mol) was added to the solution OfMe2NH (45 g, 1 mol) in CH2Cl2 (500 ml). The mixture was stirred overnight. The solid was collected by filtration. Toluene (500 mL) was added to dissolve the solid, followed by (PhS)2 (32.7 g, 0.15 mol) and Bu3P (40 g, 0.2 mol). The mixture was heated to 8O0C and stirred for 18 h. The solvent was removed in vacuo. The residue was subjected to flash column chromatography on silica gel eluting with 50% EtO Ac/petroleum ether to provide 0208 (13.4 g, 35.3%). LC- MS: 373 [M+l]+. 1H NMR (CDCl3):^ 2.46 (m, IH), 2.82 (s, 3H), 2.84 (s, 3H), 2.88 (m, IH), 3.20 (m, IH), 3.33 (m, IH), 4.13 (m, IH), 5.07 (s, 2H), 6.30 (d, J= 9.0 Hz, IH), 7.15 (m, IH), 7.32 (m, 9H)., 118399-28-3
As the paragraph descriping shows that 118399-28-3 is playing an increasingly important role.
Reference£º
Patent; CURIS, INC.; WO2009/36051; (2009); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem