Downstream synthetic route of 184950-35-4

184950-35-4 (Tetrahydrofuran-3-yl)methanamine hydrochloride 17750392, aTetrahydrofurans compound, is more and more widely used in various fields.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.184950-35-4,(Tetrahydrofuran-3-yl)methanamine hydrochloride,as a common compound, the synthetic route is as follows.

Production Example 127 (0443) Tetrahydrofuran-3-ylmethylamine hydrochloride (0.45 g, 3.26 mmol) and triethylamine (0.33 g, 3.26 mmol) were added to chloroform (amylene addition product) (13 mL). 5-(2-Cyclopentylethyl)oxymethylisoxazole-3-carboxylic acid (0. 65 g, 2.72 mmol), 1-hydroxybenzotriazole (0.04 g, 0.27 mmol) and 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (0.63 g, 3.26 mmol) were added to the mixture at room temperature, and the mixture was stirred overnight. Then, dilute hydrochloric acid was added thereto, and the mixture was extracted twice with chloroform. The organic layer was washed with a saturated aqueous sodium bicarbonate solution, dried over anhydrous sodium sulfate, and then concentrated under reduced pressure. The residue was applied to a silica gel column chromatography to obtain 0.85 g of N-(tetrahydrofuran-3-ylmethyl)-5-(2-cyclopentylethyl)oxymet hylisoxazole-3-carboxamide (hereinafter, referred to as Compound of Present Invention (132)) represented by the following formula. 1H-NMR(CDCl3, TMS, delta(ppm)):1.05-1.13(2H, m), 1.46-1.90(10H, m), 2.05-2.13(1H, m), 2.53-2.63(1H, m), 3.45-3.48(2H, m), 3.52-3.56(2H, m), 3.57-3.61(1H, m), 3.74-3.80(1H, m), 3.84-3.94(2H, m), 4.61(2H, s), 6.70(1H, s), 6.94(1H, br s), 184950-35-4

184950-35-4 (Tetrahydrofuran-3-yl)methanamine hydrochloride 17750392, aTetrahydrofurans compound, is more and more widely used in various fields.

Reference£º
Patent; Sumitomo Chemical Company, Limited; MITSUDERA, Hiromasa; AWASAGUCHI, Kenichiro; AWANO, Tomotsugu; UJIHARA, Kazuya; EP2952096; (2015); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

Brief introduction of 118399-28-3

As the paragraph descriping shows that 118399-28-3 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.118399-28-3,(R)-Benzyl (5-oxotetrahydrofuran-3-yl)carbamate,as a common compound, the synthetic route is as follows.

Compound 0101 (24 g, 0.1 mol) was added to the solution OfMe2NH (45 g, 1 mol) in CH2Cl2 (500 ml). The mixture was stirred overnight. The solid was collected by filtration. Toluene (500 mL) was added to dissolve the solid, followed by (PhS)2 (32.7 g, 0.15 mol) and Bu3P (40 g, 0.2 mol). The mixture was heated to 8O0C and stirred for 18 h. The solvent was removed in vacuo. The residue was subjected to flash column chromatography on silica gel eluting with 50% EtO Ac/petroleum ether to provide 0208 (13.4 g, 35.3%). LC- MS: 373 [M+l]+. 1H NMR (CDCl3):^ 2.46 (m, IH), 2.82 (s, 3H), 2.84 (s, 3H), 2.88 (m, IH), 3.20 (m, IH), 3.33 (m, IH), 4.13 (m, IH), 5.07 (s, 2H), 6.30 (d, J= 9.0 Hz, IH), 7.15 (m, IH), 7.32 (m, 9H)., 118399-28-3

As the paragraph descriping shows that 118399-28-3 is playing an increasingly important role.

Reference£º
Patent; CURIS, INC.; WO2009/36051; (2009); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

Simple exploration of 453-20-3

453-20-3, As the paragraph descriping shows that 453-20-3 is playing an increasingly important role.

453-20-3, 3-Hydroxytetrahydrofuran is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of tetrahydrofuran-3-ol (92.5 g, 1.05 mol) indichloromethane (2000 mL) was added pyridinium chlorochromate (454 g, 2.10 mol) and silica gel (500 g). The reaction mixture was heated to 40C. After 16 hours, the reaction mixture was filtered, and the filtrate was concentrated under reduced pressure to afford the crude residue. The residue was purified via chromatography on silica gel (methanol/DCM, linear gradient) to afford dihydrofuran-3(2H)-one.

453-20-3, As the paragraph descriping shows that 453-20-3 is playing an increasingly important role.

Reference£º
Patent; MERCK SHARP & DOHME CORP.; ALTMAN, Michael, D.; BIENSTOCK, Corey, E.; BUTCHER, John, W.; CHILDERS, Kaleen Konrad; DI FRANCESCO, Maria Emilia; DONOFRIO, Anthony; ELLIS, John Michael; FISCHER, Christian; HAIDLE, Andrew, M.; JEWELL, James, P.; KNOWLES, Sandra Lee; NORTHRUP, Alan, B.; OTTE, Ryan, D.; PETERSON, Scott, L.; SMITH, Graham Frank; WO2013/52394; (2013); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

Some tips on 124391-75-9

The synthetic route of 124391-75-9 has been constantly updated, and we look forward to future research findings.

124391-75-9, (S)-(Tetrahydrofuran-3-yl)methanol is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a stirring solution of (3-oxolanyl)methan-1-ol (25 g, 245 mmol) and triethylamine (34.37 mL, 245 mmol) in dry dichloromethane (250 mL) at 0¡ã C under N2 atmosphere was added dropwise methanesulfonyl chloride (18.94 mL, 245 mmol). The reaction mixture was stirred overnight after warming to room temperature, then a saturated solution of NaHCO3 (100 mL) was added and the mixture stirred for another 30 min. The biphasic mixture was separated and the organic layer was discarded. The aqueous layer was extracted with dichloromethane (3 x 25 mL) and the combined dichloromethane extracts were dried (Na2SO4), filtered and concentrated by rotary evaporation to give 42.16 g of (3-oxolanyl) methyl methanesulfonate (99 percent) as a light brown liquid., 124391-75-9

The synthetic route of 124391-75-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; TARGACEPT, INC.; WO2004/5293; (2004); A2;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

Simple exploration of 184950-35-4

184950-35-4, The synthetic route of 184950-35-4 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.184950-35-4,(Tetrahydrofuran-3-yl)methanamine hydrochloride,as a common compound, the synthetic route is as follows.

Tetrahydrofuran-3-ylmethylamine hydrochloride (0.16 g, 1.2 mmol) And triethylamine (0.12 g, 1.2 mmol) Was added to chloroform (amylene added product) (5 mL). To the mixture, 5- (3-phenylbenzyl) oxymethyl isoxazole-3-carboxylic acid (0.25 g, 0.8 mmol) at room temperature, 1-Hydroxybenzotriazole (0.01 g, 0.08 mmol) And 1-ethyl-3- (3-dimethylaminopropyl) carbodiimide hydrochloride (0.22 g, 1.2 mmol) After stirring for 3 hours, Dilute hydrochloric acid was added, It was extracted twice with chloroform. The organic layer was washed with saturated sodium bicarbonate water, After drying with anhydrous sodium sulfate, And concentrated under reduced pressure. The residue was subjected to silica gel column chromatography, Represented by the following equation N- (tetrahydrofuran-3-ylmethyl) -5- (3-phenylbenzyl) oxymethyl isoxazole-3-carboxamide (Hereinafter referred to as present amide compound (113)) 0.21 g was obtained.

184950-35-4, The synthetic route of 184950-35-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SUMITOMO CHEMICAL COMPANY LIMITED; SUMITA, YUSUKE; (264 pag.)JP2015/51963; (2015); A;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

Brief introduction of 696-59-3

696-59-3 2,5-Dimethoxytetrahydrofuran 79098, aTetrahydrofurans compound, is more and more widely used in various fields.

696-59-3,696-59-3, 2,5-Dimethoxytetrahydrofuran is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

NH2 r- OCH3 HOAc CH30 0 O /1 O oC h pale 2 -75 Lit.: Faigl, F.; Fogassy, K.; Thuner, A.; Toke, L.; Tetrahedron 1997,53, 4883. 10. 95 g (83 mmol.) of 1 and 4.7 g (38 mmol.) of 2 are refluxed for 2 hours in 10 ml of glacial acetic acid. The colour of the solution changes from yellow through red to black. The mixture is then diluted with 75 ml of distilled water and extracted twice with 100 ml of CHZCL2. NA2CO3 is added to the black organic solutions. After filtration and concentration (20 mbar, 50oC), a black oil is obtained and is distilled in vacuo. Yield: 4.45 g (25.7 mmol.; 75 %). 1H NMR (25oC, CDC13) : 8 (PPM) = 3. 8 (s, 3H), 6.3 (t, J = 2.2 Hz, 2H), 7.0 (m, 4H), 7.3 (M, 2H).

696-59-3 2,5-Dimethoxytetrahydrofuran 79098, aTetrahydrofurans compound, is more and more widely used in various fields.

Reference£º
Patent; DEGUSSA AG; WO2004/101581; (2004); A2;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

Analyzing the synthesis route of 88675-24-5

Big data shows that 88675-24-5 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.88675-24-5,Tetrahydrofuran-3-amine,as a common compound, the synthetic route is as follows.

To a solution of butyric acid (253 mg, 2.9 mmol) dissolved in 15 mL of water at ambient temperature, was added N-hydroxysuccinimide (330 mg, 2.9 mmol) followed by EDOHC1 (550 mg, 2.9 mmol). The reaction was stirred for 30 min before 3-aminotetrahydrofuran (250 mg, 2.9 mmol) was added. After 24 h, the solution was extracted with chloroform (3 x 5 mL). The combined chloroform layers were washed with a saturated aqueous solution of sodium bicarbonate (2 x 5 mL), dried with MgS04, filtered and the solvent removed under reduced pressure to afford 22 as a clear oil. Yield: 82.3 mg, 18percent yield. *H NMR (600 MHz, CDC13): delta 5.81 (s, 1H), 4.52-4.46 (m, 1H), 3.88 (ddd, 1H, J=8.0 Hz), 3.77 (dd, 1H, J= 5.4, 9.4 Hz), 3.76- 3.72 (m, 1H), 3.61 (dd, 1H, J=2.5, 9.4 Hz), 2.26-2.18 (m, 1H), 2.10 (t, 2H, J= 7.4 Hz), 1.79-1.71 (m, 1H), 1.61 (sex, 2H, J=7.4 Hz), 0.90 (t, 3H, J=7.4 Hz); 13C NMR (150 MHz, CDC13): delta 172.7, 73.6, 66.8, 50.1, 38.6, 33.2, 19.1, 13.7; ESI MS: Expected [M+H]+: 158.1176, observed: 158.1175; IR (cm 1): 3282, 3068, 2963, 2935, 2873, 1740, 1639, 1540, 1450, 1379, 1286, 1213, 1143, 1063, 908, 802., 88675-24-5

Big data shows that 88675-24-5 is playing an increasingly important role.

Reference£º
Patent; WISCONSIN ALUMNI RESEARCH FOUNDATION; BLACKWELL, Helen; BOURSIER, Michelle, E.; MOORE, Joseph, D.; (110 pag.)WO2017/190116; (2017); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

Downstream synthetic route of 88675-24-5

The synthetic route of 88675-24-5 has been constantly updated, and we look forward to future research findings.

88675-24-5, Tetrahydrofuran-3-amine is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

88675-24-5, 3-bromo-7-(4-methoxybenzyl)-6-methylimidazo[1 ,5-a]pyrazin-8(7H)-one (60 mg, 0.172 mmol) and tetrahydrofuran-3-amine (0.04 ml, 0.465 mmol) were mixed in NMP (2 mL) and DIPEA (0.23 ml, 1.317 mmol). (1315) The reaction was heated for 4 hours at 250¡ãC in the microwave oven. (1316) The reaction was purified on silica gel, via preparative LC-MS, and preparative TLC (10percent EtOH in ethyl acetate) to give 7-(4-methoxybenzyl)-6-methyl-3-((tetrahydrofuran-3- yl)amino)imidazo[1 ,5-a]pyrazin-8(7/-/)-one (2 mg, 0.005 mmol) in 3percent yield. (1317) 1H NMR (600 MHz, Dimehtylsulfoxide-c/6) delta 8.50 (m, NH), 7.68 (s, 1 H), 7.31 (s, 1 H) 7.22 (d, J = 7.1 Hz, 2H), 6.88 (d, J = 7.1 Hz, 2H), 4.87 (m, 1 H), 4.35 (d, J = 14 Hz, 2H), 4.1 1 (m, 1 H), 4.02 (m, 1 H), 3.92 (m, 1 H), 3.86 (m, 1 H), 3.71 (s, 3H), 2.60 (m, 1 H), 2.5 (m, 1 H) 2.31 (s, 3H). (1318) LC-MS: ?R = 0.54 min (method 19), m/z = 355.2 [M + H]+.

The synthetic route of 88675-24-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; H. LUNDBECK A/S; KEHLER, Jan; RASMUSSEN, Lars, Kyhn; LANGGARD, Morten; JESSING, Mikkel; VITAL, Paulo, Jorge, Vieira; JUHL, Karsten; (159 pag.)WO2018/78042; (2018); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

Simple exploration of 88675-24-5

As the paragraph descriping shows that 88675-24-5 is playing an increasingly important role.

88675-24-5, Tetrahydrofuran-3-amine is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

88675-24-5, To (2-bromo-6,7-dihydrothiazolo[5 ,4-c]pyridin-5(4H)-yl)(4-methyl- 1 H-indol-2-yl)methanone (0.035 g, 0.093 mmol) was added tetrahydrofuran-3-amine (0.500 ml, 5.81 mmol). The mixture was stirred at 70¡ãC for 72h then concentrated under reduced pressure, and purified by silica gelchromatography to give the desired product (0.011 g, 33percent yield) Rt (Method A) 3.32 mins, m/z 341 [M+H].

As the paragraph descriping shows that 88675-24-5 is playing an increasingly important role.

Reference£º
Patent; AICURIS GMBH & CO. KG; DONALD, Alastair; URBAN, Andreas; BONSMANN, Susanne; WEGERT, Anita; GREMMEN, Christiaan; SPRINGER, Jasper; (376 pag.)WO2019/86141; (2019); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

New learning discoveries about 184950-35-4

184950-35-4, 184950-35-4 (Tetrahydrofuran-3-yl)methanamine hydrochloride 17750392, aTetrahydrofurans compound, is more and more widely used in various fields.

184950-35-4, (Tetrahydrofuran-3-yl)methanamine hydrochloride is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Production Example 141 (0461) 5-(6-Phenoxyhexyl)isoxazole-3-carboxylic acid (0.72 g, 2.5 mmol), tetrahydrofuran-3-ylmethylamine hydrochloride (0.42 g, 3.0 mmol), triethylamine (0.31 g, 3.0 mmol) and 1-hydroxybenzotriazole (0.04 g, 0.30 mmol) were added to chloroform (amylene addition product) (8 mL). 1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (0.58 g, 2. mmol) was added to the mixture at room temperature, and the mixture was stirred overnight and then concentrated under reduced pressure. Dilute hydrochloric acid was added to the concentrate, and the mixture was extracted twice with ethyl acetate. The organic layer was washed with saturated saline water, dried over anhydrous sodium sulfate, and then concentrated under reduced pressure. The residue was applied to a silica gel column chromatography to obtain 0.77 g of N-(tetrahydrofuran-3-ylmethyl)-5-(6-phenoxyhexyl)isoxazole-3-carboxamide (hereinafter, referred to as Compound of Present Invention (148)) represented by the following formula. 1H-NMR(CDCl3, TMS, delta(ppm)):1.40-1.56(4H, m), 1.64-1.68(1H, m), 1.72-1.82(4H, m), 2.04-2.13(1H, m), 2.52-2.62(1H, m), 2.81(2H, t), 3.46(2H, dt), 3.58(1H, dd), 3.73-3.79(1H, m), 3.86(1H, dd), 3.88-3.93(1H, m), 3.95(2H, t), 6.45(1H, s), 6.87-6.95(4H, m), 7.27-7.29(2H, m)

184950-35-4, 184950-35-4 (Tetrahydrofuran-3-yl)methanamine hydrochloride 17750392, aTetrahydrofurans compound, is more and more widely used in various fields.

Reference£º
Patent; Sumitomo Chemical Company, Limited; MITSUDERA, Hiromasa; AWASAGUCHI, Kenichiro; AWANO, Tomotsugu; UJIHARA, Kazuya; EP2952096; (2015); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem