With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.124391-75-9,(S)-(Tetrahydrofuran-3-yl)methanol,as a common compound, the synthetic route is as follows.
124391-75-9, Example 338E (100 mg, 0.20 mmol), (tetrahydro-furan-3-yl) -methanol (82 mg, 0.80 mmol), DBAD (92 mg, 0.40 mmol), PPh-polymer supported (133 mg, 0.40 mmol) and THF (5 mL) were mixed, and shaken overnight. The mixture was filtered. The filtrate was concentrated. To the residue was added methanol (8.0 mL) and 4N HCL in dioxane (0.50 mL). The mixture was stirred at room temperature for 8 hours. All the solvents were removed. The residue was washed with ethyl acetate (10 mLx2), and dried to give the desired product (48 mg, 67%).
The synthetic route of 124391-75-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; ABBOTT LABORATORIES; WO2004/80973; (2004); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem