184950-35-4, (Tetrahydrofuran-3-yl)methanamine hydrochloride is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,184950-35-4
5-propargyloxymethyl isoxazole-3-carboxylic acid (2.88 g, 15.9 mmol),Tetrahydrofuran-3-ylmethylamine hydrochloride (2.72 g, 19.8 mmol),Triethylamine (1.94 g, 19.8 mmol)And 1-hydroxybenzotriazole (0.22 g, 1.59 mmol)Was added to chloroform (amylene addition product) (30 mL).To the mixture,1-Ethyl-3- (3-dimethylaminopropyl) carbodiimide hydrochloride (3.80 g, 19.8 mmol) was added at room temperature,Stir at room temperature overnight,And concentrated under reduced pressure.Dilute hydrochloric acid was added to the concentrate,Extracted twice with ethyl acetate.The organic layer was washed with saturated brine,After drying with anhydrous sodium sulfate, decreaseAnd concentrated under reduced pressure.The residue was subjected to silica gel column chromatography,Represented by the following equationN- (tetrahydrofuran-3-ylmethyl) -5-propargyloxymethylisoxazole-3-carboxamide(Hereinafter referred to as the present amide compound (339))2.95 g was obtained.
184950-35-4 (Tetrahydrofuran-3-yl)methanamine hydrochloride 17750392, aTetrahydrofurans compound, is more and more widely used in various fields.
Reference£º
Patent; SUMITOMO CHEMICAL COMPANY LIMITED; SUMITA, YUSUKE; (264 pag.)JP2015/51963; (2015); A;,
Tetrahydrofuran – Wikipedia
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