86087-23-2, (S)-(+)-3-Hydroxytetrahydrofuran is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Take 4-bromo-2-(4-fluorobenzyl)chlorobenzene 148kg,(S)-3-hydroxytetrahydrofuran (45kg) dissolved in 300kg tetrahydrofuranThe ice bath was cooled to 0C and under the protection of nitrogen, a solution of potassium tert-butoxide in tetrahydrofuran was added dropwise.(tert-butanol potassium 56kg, tetrahydrofuran 150kg) 30min drop, drop is completed,5-10 C reaction 1h, after the end of the reaction, add 300kg of water to quench the reaction,Tetrahydrofuran was recovered by distillation and the residue was extracted with 300 kg of ethyl acetate and dried over anhydrous sodium sulfate.After filtration, the solvent was recovered from the filtrate and recrystallized from 70% ethanol to obtain 161 kg of a white solid with a yield of 88%., 86087-23-2
The synthetic route of 86087-23-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Jiangsu Engineering Polytechnic College; Feng Chengliang; Yan Bin; (12 pag.)CN107652278; (2018); A;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem