17347-61-4, 2,2-Dimethylsuccinicanhydride is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A stirring solution of compound 17-1 (112 mg, 0.232 mmol), DMAP (28 mg, 0.232 mmol) and 2,2-dimethylsuccinic anhydride (89 mg, 0.695 mmol) in dry pyridine (4 mL) is heated for 4 hours at 120¡ãC. Another 90 mg (0.7 mmol) of anhydride is added and heating is continued overnight. The mixture is concentrated to dryness and the residue is diluted in ethyl acetate, washed twice with HCl 1 N, water and brine, dried over sodium sulfate and concentrated to dryness. The residue is purified by flash chromatography on silica gel (ethyl acetate/hexanes 10percent to 30percent) to yield the title compound 14-1 as a white solid (87 mg, 61percent).1H NMR (400 MHz, DMSOd6): delta [ppm] 12.16 (s, 1 H), 6.33 (s, 1 H), 4.64 (d, 1 H), 4.54 (s, 1 H), 4.35 (d x d, 1 H), 3.47 (s, 3H), 2.73 (m, 1 H), 2.53 (d, 1 H), 2.45 (d, 1 H), 2.42 (m, 1 H), 2.15 (m, 1 H), 1.92 (m, 1 H), 1.75 (m, 1 H), 1.70-0.90 (m, 20H), 1.62 (s, 3H), 1.15 (s, 3H), 1.14 (s, 3H), 0.95 (s, 3H), 0.91 (s, 3H), 0.89 (s, 3H), 0.84 (s, 3H), 0.80 (s, 3H). LC/MS: m/z = 614.72 (M+H+). HPLC (Method A): tR = 31.62 min., 17347-61-4
The synthetic route of 17347-61-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; VIROCHEM PHARMA INC.; WO2009/100532; (2009); A1;,
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