17347-61-4, 2,2-Dimethylsuccinicanhydride is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
4-(4-Bromophenyl)-2, 2-dimethyl-4-oxo-butyric acid 67. To a stirred suspension of 2,2-dimethylsuccinic anhydride (0.641 g, 5.0 mmol) in bromobenzene (3.3 mL), cooled to -10¡ã C (ice/acetone bath) was added aluminium trichloride (1.34 g, 10 mmol) and the reaction was allowed to warm slowly to rt with stirring overnight. The resulting brown solution was poured into cooled (ice bath) aqueous HCl (10 mL, 18percent) and stirred for a further 30 min while the solution was allowed to warm to r.t. No precipitate formed therefore DCM (10 mL) was added and the organic layer was separated and concentrated under reduced pressure to give a solution of the product in PhBr. To this was added hexane followed by a small amount of DCM and the resulting white needles were collected by filtration. Yield 51percent: 1H NMR delta (270 MHz, DMSO-d6) 1.24 (6H, s), 3.29 (2H, s), 7.69 (2H5 d, J= 8.7 Hz), 7.88 (2H, d, J= 8.7 Hz), 7.96 (IH5 s); HPLC > 93percent (R1 2.87, 70percent MeCN in H2O); APCI (M-H)” 283.15, 285.10 m/z.
17347-61-4, As the paragraph descriping shows that 17347-61-4 is playing an increasingly important role.
Reference£º
Patent; STERIX LIMITED; WO2007/96647; (2007); A2;,
Tetrahydrofuran – Wikipedia
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