Day: September 25, 2020

21461-84-7, (S)-(+)-5-Oxo-2-tetrahydrofurancarboxylic Acid is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

70.0 g (0.538 mol) of compound 1A is dissolved in 315 ml of CH2Cl2. The solution is cooled and kept at 3C under N2 atmosphere. 170.7 g (1.345 mol) of oxalyl chloride is slowly added afterwards 0.80 ml of DMF is carefully added to the solution. After completion of the addition, the mixture is warmed to room temperature and stirred for 2h. Then, the solvent is evaporated under reduced pressure. The remaining material is dissolved in 15 ml of CH2Cl2 and the solvent is evaporated once again. 69.2 g (0.646 mol) of 2,6-lutidine and 79.8 g (1.076 mol) of t-BuOH are dissolved in 350 ml of CH2Cl2. The mixture is cooled to 3C. Then a solution of acyl chloride previously synthesized in 50 ml of CH2Cl2 is added dropwise over a period of 10 min. At the end of the addition, the mixture is warmed to room temperature and stirred for 12 h. Solvent is evaporated. The remaining oil is dissolved in 500 ml of ethyl acetate and purified on Silica plug (around 2L of ethyl acetate). The solution is concentrated and treated with charcoal during 30 min. After filtration on celite, the solvent is evaporated under reduced pressure to obtain a yellow solution which is kept for recrystallization to obtain compound 2A as pale yellow powder., 21461-84-7

Big data shows that 21461-84-7 is playing an increasingly important role.

Reference£º
Patent; OctreoPharm Schiences GmbH; Chematech; Boschetti, Frederic, Dr.; Bouterfa, Hakim, Dr.; Kaufmann, Jens, Dr.; (18 pag.)EP3015462; (2016); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

17347-61-4, 2,2-Dimethylsuccinicanhydride is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A stirring solution of compound 17-1 (112 mg, 0.232 mmol), DMAP (28 mg, 0.232 mmol) and 2,2-dimethylsuccinic anhydride (89 mg, 0.695 mmol) in dry pyridine (4 mL) is heated for 4 hours at 120¡ãC. Another 90 mg (0.7 mmol) of anhydride is added and heating is continued overnight. The mixture is concentrated to dryness and the residue is diluted in ethyl acetate, washed twice with HCl 1 N, water and brine, dried over sodium sulfate and concentrated to dryness. The residue is purified by flash chromatography on silica gel (ethyl acetate/hexanes 10percent to 30percent) to yield the title compound 14-1 as a white solid (87 mg, 61percent).1H NMR (400 MHz, DMSOd6): delta [ppm] 12.16 (s, 1 H), 6.33 (s, 1 H), 4.64 (d, 1 H), 4.54 (s, 1 H), 4.35 (d x d, 1 H), 3.47 (s, 3H), 2.73 (m, 1 H), 2.53 (d, 1 H), 2.45 (d, 1 H), 2.42 (m, 1 H), 2.15 (m, 1 H), 1.92 (m, 1 H), 1.75 (m, 1 H), 1.70-0.90 (m, 20H), 1.62 (s, 3H), 1.15 (s, 3H), 1.14 (s, 3H), 0.95 (s, 3H), 0.91 (s, 3H), 0.89 (s, 3H), 0.84 (s, 3H), 0.80 (s, 3H). LC/MS: m/z = 614.72 (M+H+). HPLC (Method A): tR = 31.62 min., 17347-61-4

The synthetic route of 17347-61-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; VIROCHEM PHARMA INC.; WO2009/100532; (2009); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

915095-89-5, (S)-3-(4-(5-Bromo-2-chlorobenzyl)phenoxy)tetrahydrofuran is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Add 36.6g of compound of Formula 5, 350ml of dioxane, 38g of bis(pinacolato)diboron(formula 6), 30g of potassium acetate, 1.47g of dppfPdCl, and heat up the oil bath to 100 with nitrogen filling. The reaction was carried out at a temperature of 8 C for 8 hours. After the reaction, the temperature was lowered to room temperature, filtered, and the filtrate was washed with water and concentrated to obtain a yellow solid, which was refined by adding ethanol to obtain a white solid (Formula 7), 26.1 g. The yield was 71.3%. HPLC: 98.6%., 915095-89-5

915095-89-5 (S)-3-(4-(5-Bromo-2-chlorobenzyl)phenoxy)tetrahydrofuran 15941217, aTetrahydrofurans compound, is more and more widely used in various fields.

Reference£º
Patent; Huanggang Luban Pharmaceutical Co., Ltd.; Yang Xiaolong; Pei Pibing; Zhang Jianjun; Yang Tiebo; Chen Qian; (22 pag.)CN110698467; (2020); A;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

184950-35-4, (Tetrahydrofuran-3-yl)methanamine hydrochloride is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Production Example 9 (0320) 1-Benzyl-1H-1,2,3-triazole-4-carboxylic acid (0.96 g, 4.7 mmol), tetrahydrofuran-3-ylmethylamine hydrochloride (0.71 g, 5.2 mmol), triethylamine (1.01 g, 10 mmol) and 1-hydroxybenzotriazole (0.08 g, 0.52 mmol) were added to chloroform (amylene addition product) (30 mL). 1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (1.00 g, 4.2 mmol) was added to the mixture at room temperature, and the mixture was stirred overnight and then concentrated under reduced pressure. Dilute hydrochloric acid was added to the concentrate, and the mixture was extracted twice with ethyl acetate. The organic layer was washed with saturated saline water, dried over anhydrous sodium sulfate, and then concentrated under reduced pressure. The residue was applied to a silica gel column chromatography to obtain 0.86 g of 31-benzyl-1H-1,2,3-triazole-4-carboxamide (hereinafter, referred to as Compound of Present Invention (9)) represented by the following formula. 1H-NMR(CDCl3, TMS, delta(ppm)): 1. 6.4-1 . 72 (1H, m), 2.03-2.11(1H, m), 2.54-2.59(1H, m), 3.46(2H, dd), 3.58(1H, dd), 3.75(1H, q), 3.93-3.84(2H, m), 5.55(2H, s), 7.41-7.27(5H, m), 7.97(1H, s), 184950-35-4

184950-35-4 (Tetrahydrofuran-3-yl)methanamine hydrochloride 17750392, aTetrahydrofurans compound, is more and more widely used in various fields.

Reference£º
Patent; Sumitomo Chemical Company, Limited; MITSUDERA, Hiromasa; AWASAGUCHI, Kenichiro; AWANO, Tomotsugu; UJIHARA, Kazuya; EP2952096; (2015); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

111769-27-8, (R)-Tetrahydrofuran-3-amine 4-methylbenzenesulfonate is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(b) To ethyl l-(6-chloro-l-(3,5-dimethylphenyl)-5-methyl-lH-benzo[d]imidazol-2-yl)piperidine- 4-carboxylate (8.6 mg) was added ethanol (2 mL) and aqueous sodium hydroxide (1 mL, 2 N). The reaction mixture was stirred at 4O0C for two hours, neutralized with aqueous hydrochloric acid (2 N) and concentrated in vacuo. The residue was mixed (R)-(+)-tetrahydrofuran-3 -amine A- methylbenzenesulfonate (6.3 mg, 0.024 mmol), 2-(7-aza-lH-benzotriazole-l-yl)-l, 1,3,3- tetramethyluronium hexafluorophosphate (HATU, 9.2 mg, 0.024 mmol), 7V,iV-diisopropyl- ethylamine (Hunig’s base, DIEA, 7.8 mg, 0.060 mmol) and N,N-dimethylformamide (5 mL) was stirred at room temperature over the weekend. The reaction mixure was concentrated in vacuo, the residue subjected to preperative hplc (Preparative RP-LC was performed on a Gilson system equipped with a Zorbax SB-C8 (5 mum, 21.2 x 150 mm) column, using methano I/water (0.05% formic acid) gradients at a flow rate of 15 mL/min with UV (214 or 254 nm) and MS (ESI) detection) to give 7.7 mg (82 % yield) (R)-l-(6-chloro-l-(3,5-dimethylphenyl)-5-methyl-lH- benzo[d]imidazol-2-yl)-N-(tetrahydrofuran-3-yl)piperidine-4-carboxamide. MS (m/z) 467.0 (M+l)., 111769-27-8

111769-27-8 (R)-Tetrahydrofuran-3-amine 4-methylbenzenesulfonate 14243169, aTetrahydrofurans compound, is more and more widely used in various fields.

Reference£º
Patent; NOVASAID AB; WANNBERG, Johan; ALTERMAN, Mathias; MALM, Johan; STENBERG, Patric; WESTMAN, Jacob; WALLBERG, Hans; WO2011/23812; (2011); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1679-47-6,3-Methyldihydrofuran-2(3H)-one,as a common compound, the synthetic route is as follows.

Example 11 Hydrogenation of alpha-methyl-gamma-butyrolactone [Ru2(mu-Cl)3(triphos)2]Cl (3.0 mg), potassium tert-butoxide (5.5 mg), and 1. 5 ml of methanol were added into a 20-ml Schlenk tube under a nitrogen atmosphere, and the mixture was stirred for 20 minutes at room temperature. This solution and alpha-methyl-gamma-butyrolactone (0.12 g) were added into a 100-ml autoclave having a stirrer placed inside, under a nitrogen atmosphere. The autoclave was purged with hydrogen, and then hydrogen was further included in the autoclave up to 4.0 MPa. The contents of the autoclave were heated and stirred at 100C for 13 hours. After cooling, the reaction liquid was analyzed by gas chromatography, and it was found that 1,4-pentanediol was produced at a yield of 39.7%., 1679-47-6

The synthetic route of 1679-47-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Takasago International Corporation; EP2141142; (2010); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17347-61-4,2,2-Dimethylsuccinicanhydride,as a common compound, the synthetic route is as follows.

Step E: Intermediate 26-2 To a solution of the intermediate 25-2 in pyridine (1 mL) were added DMAP (150 mg, 1.171 mmol) and 3, 3-dimethyldihydro-2,5-furandione (480 mg, 3.93 mmol). The reaction mixture was stirred at 80 ¡ãC for 1.5 h. After cooling down to room temperature, the reaction mixture was extracted with DCM (50 mL x 3). The organic phase was separated, washed with water, brine, and dried with Na2S04. Removal of the solvent provided a crude product, which was purified by column chromatography on silica gel (PE: EtOAc = 3:1 ) to afford the intermediate 26-2 (240 mg, 0.337 mmol, 70.3 percent yield) as a white solid.

17347-61-4, 17347-61-4 2,2-Dimethylsuccinicanhydride 87067, aTetrahydrofurans compound, is more and more widely used in various fields.

Reference£º
Patent; GLAXOSMITHKLINE LLC; GAO, Daxin; HAN, Nianhe; JOHNS, Brian; JIN, Zhimin; NING, Fangxian; TANG, Jun; WU, Yongyong; YANG, Heping; WO2013/20245; (2013); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

17347-61-4, 2,2-Dimethylsuccinicanhydride is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The compound 6 (349 mg, 0.5 mmol) is dissolved in anhydrous pyridine (8 ml) in, adding 2, 2 – dimethyl succinic anhydride (320 mg, 2.5 mmol), DMAP (61 mg, 0.5 mmol), after dissolving completely, microwave reactor is heated to 160 ¡ãC, reaction 3 h. The end of the reaction, by adding ethyl acetate (50 ml), for 10percent HCl to adjust the pH 4 – 5; organic layer is saturated salt water washing (25 ml ¡Á 3), dried with anhydrous sodium sulfate, filtered, concentrated under reduced pressure to remove the solvent, silica gel column chromatography (hexane: ethyl acetate=1:1), to obtain white solid 302 g, is compound 9, yield 73percent.

17347-61-4, As the paragraph descriping shows that 17347-61-4 is playing an increasingly important role.

Reference£º
Patent; Chen Zhong; Duan Huaqing; Yang Shilin; Li Guoxiong; (26 pag.)CN109485688; (2019); A;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

16874-33-2, Tetrahydrofuran-2-carboxylic acid is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Add 2-(5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidine-4,5,6- to a 50 mL two-necked vial Triamine (0.10 g, 0.27 mmol),Tetrahydrofuran-2-carboxylic acid (0.046 g, 0.40 mmol)And N,N-dimethylformamide (10.0 mL),2-(7-Azobenzotriazole)-N,N,N’,N’-tetramethyluronium hexafluorophosphate added at 0 ¡ãC(0.15g, 0.39mmol)N,N-Diisopropylethylamine (0.13 mL, 0.79 mmol) was stirred at room temperature overnight.Quenched with water, extracted with ethyl acetate (30 mL¡Á2).The organic phase was washed sequentially with water (30 mL) and brine (30 mL).Dry over anhydrous sodium sulfate, suction filtration,The residue was purified by silica gel column chromatography (dichloromethane/methanol (v/v) = 80/1, 0.5percent triethylamine).A white solid (0.067 g, 53.0percent) was obtained.

16874-33-2, 16874-33-2 Tetrahydrofuran-2-carboxylic acid 86079, aTetrahydrofurans compound, is more and more widely used in various fields.

Reference£º
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Wang Xiaojun; Zuo Yinglin; Yu Chuan; Yang Chuanwen; Wang Jiancheng; Li Jing; Cao Shengtian; Wu Fangyuan; Zhang Yingjun; S ¡¤geerdeman; (79 pag.)CN108690016; (2018); A;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

17347-61-4, 2,2-Dimethylsuccinicanhydride is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

4-(4-Bromophenyl)-2, 2-dimethyl-4-oxo-butyric acid 67. To a stirred suspension of 2,2-dimethylsuccinic anhydride (0.641 g, 5.0 mmol) in bromobenzene (3.3 mL), cooled to -10¡ã C (ice/acetone bath) was added aluminium trichloride (1.34 g, 10 mmol) and the reaction was allowed to warm slowly to rt with stirring overnight. The resulting brown solution was poured into cooled (ice bath) aqueous HCl (10 mL, 18percent) and stirred for a further 30 min while the solution was allowed to warm to r.t. No precipitate formed therefore DCM (10 mL) was added and the organic layer was separated and concentrated under reduced pressure to give a solution of the product in PhBr. To this was added hexane followed by a small amount of DCM and the resulting white needles were collected by filtration. Yield 51percent: 1H NMR delta (270 MHz, DMSO-d6) 1.24 (6H, s), 3.29 (2H, s), 7.69 (2H5 d, J= 8.7 Hz), 7.88 (2H, d, J= 8.7 Hz), 7.96 (IH5 s); HPLC > 93percent (R1 2.87, 70percent MeCN in H2O); APCI (M-H)” 283.15, 285.10 m/z.

17347-61-4, As the paragraph descriping shows that 17347-61-4 is playing an increasingly important role.

Reference£º
Patent; STERIX LIMITED; WO2007/96647; (2007); A2;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem