10374-51-3, 5-(Hydroxymethyl)dihydrofuran-2(3H)-one is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
2.1 mL of trifluoromethanesulfonic acid was added to a solution of 13.8 g of 5-(hydroxymethyl)oxolane-2-one and 19.0 g of 2,4,6-tris(benzyloxy)-1,3,5-triazine in 150 mL of dioxane at a temperature of 5 C. to 10 C., and the obtained mixture was then stirred at room temperature for 5 hours. Thereafter, the reaction mixture was added to a mixture of 400 mL of ethyl acetate and 300 mL of a saturated sodium hydrogen carbonate aqueous solution. The organic layer was fractionated, and it was successively washed with 300 mL of water and 300 mL of a saturated sodium chloride aqueous solution, and was then dried over anhydrous sodium sulfate. The solvent was distilled away under reduced pressure, and the obtained residue was then purified by silica gel column chromatography (ethyl acetate/hexane=2/3 to 1/1), so as to obtain 22.4 g of 5-((benzyloxy)methyl)oxolane-2-one in the form of a colorless oily product. 1H-NMR (CDCl3) delta value: 7.33-7.28 (5H, m), 4.68-4.61 (1H, m), 4.572 (1H, s), 4.566 (1H, s), 3.68 (1H, dd, J=10.8, 4.5 Hz), 3.58 (1H, dd, J=10.8, 4.2 Hz), 2.57-2.42 (2H, m), 2.35-2.06 (2H, m), 10374-51-3
The synthetic route of 10374-51-3 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; FUJIFILM CORPORATION; NAKAMURA, Kouki; SHIMAMURA, Satoshi; IMOTO, Junichi; TAKAHASHI, Motomasa; WATANABE, Katsuyuki; WADA, Kenji; FUJINO, Yuuta; MATSUMOTO, Takuya; TAKAHASHI, Makoto; OKADA, Hideki; YAMANE, Takehiro; ITO, Takayuki; US2015/152131; (2015); A1;,
Tetrahydrofuran – Wikipedia
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