453-20-3, 3-Hydroxytetrahydrofuran is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
The compound tetrahydrofuran-3-ol (1.8 g, 20.0 mmol) was dissolved in DCM (50 mL), cooled to 0 C and then Et3N (3.0 mL, 22.0 mmo1) was added slowly to the reaction followed by MsCl (1.7 mL, 22.0 mmo 1) and a catalytic amount of DMAP were added successively, stirred overnight at room temperature, diluted with DCM (50 mL), washed with water (30 mL ¡Á 2) and separated. The organic phase was dried over anhydrous Na 2 SO 4, Concentration under reduced pressure gave the crude product as a light yellow oil (3.0 g, 90%) which was used directly in the next reaction without further purification.The compound 4-iodo-1H-pyrazole (776 mg, 4.0 mmol) was dissolved in dry DMF (50 mL), cooled to 0 C and then NaH (240 mg, 8.0 mmo 1, 80% NaH / mineral oil) was added and stirring was continued for 1 hour at 0 C. Then a solution of the oil obtained in the previous step (731 mg, 4.4 mmol) in DMF (10 mL) was added dropwise. The reaction was heated to 100 C. and reaction 24 After cooling to room temperature, the reaction was quenched by addition of water (0.5 mL), concentrated under reduced pressure and the residue suspended in DCM (50 mL). The resulting mixture was washed with water (30 mL), separated and the organic phase dried over anhydrous Na 2 SO 4 , Concentrated under reduced pressure to give the title compound as a white solid (1.0 g, 90%).
453-20-3, The synthetic route of 453-20-3 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; (88 pag.)CN104119331; (2018); B;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem