With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.19311-37-6,3-Bromotetrahydrofuran,as a common compound, the synthetic route is as follows.
Step 1: Methyl 3- (cyclopropylmethoxy) -4- ( (tetrahydrofuran-3-yl) oxy) benzoate[1808]To N, N-dimethylformamide (40 mL) were added methyl 3- (cyclopropylmethoxy) -4-hydroxybenzoate (2.0 g, 9.00 mmol) , potassium carbonate (3.73 g, 27.00 mmol) and 3-bromotetrahydrofuran (2.72 g, 18.00 mmol) . The mixture was stirred at 60 for 4.5 hours. To the mixture was added water (40 mL) and the resulting mixture was extracted with ethyl acetate (50 mL ¡Á 3) . The combined organic layers were dried over anhydrous sodium sulfate and concentrated. The residue was purified by silica gel column chromatography (PE/EtOAc (v/v) 5/1) to give the title compound as a white solid (2.87 g, 100) .[1809]1H NMR (400 MHz, CDCl3) delta ppm 7.63 (dd, J1 8.4 Hz, J2 2.0 Hz, 1H) , 7.56 (d, J 1.9 Hz, 1H) , 6.85 (d, J 8.4 Hz, 1H) , 5.05 -5.02 (m, 1H) , 4.06 -4.00 (m, 3H) , 3.95 -3.91 (m, 1H) , 3.89 (s, 3H) , 3.88 (d, J 6.7 Hz, 2H) , 2.23 -2.19 (m, 2H) , 1.34 -1.28 (m, 1H) , 0.66 -0.61 (m, 2H) , 0.38 -0.34 (m, 2H) and MS-ESI: 293.3 [M+H]+., 19311-37-6
19311-37-6 3-Bromotetrahydrofuran 12929516, aTetrahydrofurans compound, is more and more widely used in various fields.
Reference£º
Patent; SUNSHINE LAKE PHARMA CO., LTD.; LIU, Bing; YU, Tianzhu; ZHANG, Yingjun; ZHANG, Xiangyu; ZHANG, Shiguo; CHENG, Changchung; ZHANG, Jiancun; WO2015/161830; (2015); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem