204512-95-8, (S)-Tetrahydrofuran-3-amine hydrochloride is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
2-Chloro-N-(5-hydroxy-2-adamantyl)-4-propan-2-yloxypyrimidine-5-carboxamide (Intermediate 39, 560 mg, 1.53 mmol), and (S)-tetrahydrofuran-3-amine hydrochloride (284 mg, 2.30 mmol) were suspended in butyronitrile (12 mL). DIPEA (0.533 mL, 3.06 mmol) was added and the mixture was sealed into a microwave vial. The reaction was heated to 150 C. for 2.5 h in the microwave reactor, then was cooled to RT. The reaction mixture was diluted with EtOAc and washed with sat. brine. The organic layer was dried over MgSO4 and concentrated. The crude product was purified by preparative HPLC to afford the title compound (149 mg, 23%); 1H NMR (400 MHz) 1.38 (6H, d), 1.47 (2H, d), 1.68 (8H, m), 1.90 (1H, m), 2.02 (3H, d), 2.13 (1H, m), 3.55 (1H, s), 3.70 (1H, dd), 3.77-3.94 (2H, m), 3.95-4.01 (1H, m), 4.39 (2H, m), 5.50 (1H, hept), 7.66 (1H, d), 7.92 (1H, m), 8.60 (1H, s); m/z MH+=417; HPLC tR=1.58 min., 204512-95-8
The synthetic route of 204512-95-8 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; ASTRAZENECA AB; US2011/92526; (2011); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem