184950-35-4, (Tetrahydrofuran-3-yl)methanamine hydrochloride is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Production Example 148 (0468) Tetrahydrofuran-3-ylmethylamine hydrochloride (250 mg, 1.82 mmol) and a 1 mol/L aqueous sodium hydroxide solution (20 mL) were simultaneously added to a toluene solution (20 mL) of 5-(1-phenylcyclopropyl)isoxazole-3-carboxylic acid chloride (< 1.83 mmol), under ice-water cooling. The mixture was vigorously stirred for 30 minutes under ice-water cooling, and then the reaction mixture was extracted twice with ethyl acetate. The organic layer was washed with saturated saline water, dried over anhydrous sodium sulfate, and then concentrated under reduced pressure. The residue was applied to a silica gel column chromatography to obtain 504 mg of N-(tetrahydrofuran-3-ylmethyl)-5-(1-phenylcyclopropyl)isoxa zole-3-carboxamide (hereinafter, referred to as Compound of Present Invention (156)) represented by the following formula. 1H-NMR(CDCl3, TMS, delta(ppm)):1.41-1.46(m, 2H), 1.60-1.70(m, 3H), 2.01-2.11(m, 1H), 2.49-2.59(m, 1H), 3.39-3.44(m, 2H), 3.56(dd, J=8.9, 5.3Hz, 1H), 3.71-3.78(m, 1H), 3.80-3.92(m, 2H), 6.13(s, 1H), 6.86(brs, 1H), 7.29-7.42(m, 5H), 184950-35-4
184950-35-4 (Tetrahydrofuran-3-yl)methanamine hydrochloride 17750392, aTetrahydrofurans compound, is more and more widely used in various fields.
Reference£º
Patent; Sumitomo Chemical Company, Limited; MITSUDERA, Hiromasa; AWASAGUCHI, Kenichiro; AWANO, Tomotsugu; UJIHARA, Kazuya; EP2952096; (2015); A1;,
Tetrahydrofuran – Wikipedia
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