With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.63095-51-2,(R)-4-Propyldihydrofuran-2(3H)-one,as a common compound, the synthetic route is as follows.
63095-51-2, Under the protection of nitrogen, brivaracetam intermediate III (128.1g, 1 mol) was dissolved in 1L in methylene chloride. Lower the temperature to 0 C. Add trimethylsilyl iodide (150 ml). The reaction solution at 20-30 C was stirred for 2 hours. Followed by adding hydrochloric acid solution (1M, 800 ml) and sodium thiosulfate aqueous solution (mass percentage of 10%, the quality percent means that the quality of the sodium thiosulfate with the percentage of the total mass of the aqueous solution of sodium thiosulfate, 400 ml. ), The aqueous phase is 1L dichloromethane extraction, the organic phase with saturated salt water washing twice, dried with anhydrous sodium sulfate, filtered, concentrated under reduced pressure to obtain brivaracetam intermediate IV (254.6g), yield 99.5%, purity: 95.6% (GC).
63095-51-2 (R)-4-Propyldihydrofuran-2(3H)-one 10997054, aTetrahydrofurans compound, is more and more widely used in various fields.
Reference£º
Patent; Shanghai Bocimed Pharmaceutical Co., Ltd.; Ying, Shuhuan; Pi, Hongjun; Chen, Jian; Zhou, Wei; Zhang, Jueming; (13 pag.)CN106588741; (2017); A;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem