With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5061-21-2,2-Bromo-4-butanolide,as a common compound, the synthetic route is as follows.
5061-21-2, Example I: Synthesis of 3- (4-nitrophenvnsulfanyl1dihvdrofuran-2(3H)-oneTo a solution of p-nitro thiophenol (10.0 g, 0.0645 mol) in dichloromethane (75 mL) under argon atmosphere at about 0C, was added triethyl amine (19.4 g, 0.1935 mol) and then added a solution of bromolactone (11.1 g, 0.067 mol) in dichloromethane (75 mL) drop wise. The reaction mixture was stirred for about 30 minutes. Subsequently, the crude compound was obtained by adding water to the reaction mixture and extracting in dichloromethane. The organic layer was dried with sodium sulphate and concentrated, purified by silica gel column, using 30% ethyl acetate/hexane as eluent to obtain the title compound.Yield: 11 gSynthetic procedure for Scheme I:
5061-21-2 2-Bromo-4-butanolide 95463, aTetrahydrofurans compound, is more and more widely used in various fields.
Reference£º
Patent; RANBAXY LABORATORIES LIMITED; KHERA, Manoj Kumar; SONI, Ajay; SATTIGERI, Jitendra; SATTIGERI, Viswajanani; DAS, Biswajit; CLIFFE, Ian A.; BHATNAGAR, Pradip Kumar; RAUF, Abdul Rehman Abdul; MUSIB, Arpita; SAHA, Subham; YADAV, Neeraj Kumar; AHAMMED, Sabir; REDDY, Ranadheer R.; RAY, Abhijit; SRIVASTAVA, Punit; DASTIDAR, Sunanda Ghosh; WO2012/38942; (2012); A1;,
Tetrahydrofuran – Wikipedia
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